Mitochondrial permeability transition (mPT) is a phenomenon that abruptly causes the flux of
low molecular weight solutes (molecular weight up to 1,500) across the generally …

Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …

Adult cardiomyocytes are postmitotic cells that undergo very limited cell division. Thus,
cardiomyocyte death as occurs during myocardial infarction has very detrimental …

Mitochondria, which is essential for adequate innate immune response, energy metabolism
and mitochondria reactive oxygen species (ROS) production, might be in the cross fire of …

Cardiac ATP production primarily depends on oxidative phosphorylation in mitochondria
and is dynamically regulated by Ca 2+ levels in the mitochondrial matrix as well as by …

Mitochondria are the subcellular bioenergetic organelles. The analysis of their morphology
and topology is essential to provide useful information on their activity and metabolism …

The mitochondrial permeability transition pore (MPTP) is a calcium-dependent, ion non-
selective membrane pore with a wide range of functions. Although the MPTP has been …

Oxygen is vital for life as it is required for many different enzymatic reactions involved in
intermediate metabolism and xenobiotic biotransformation. Moreover, oxygen consumption …

The activity of the mitochondrial permeability transition pore, mPTP, a highly regulated multi-
component mega-channel, is enhanced in aging and in aging-driven degenerative …

The design of the energy metabolism system in striated muscle remains a major area of
investigation. Here, we review our current understanding and emerging hypotheses …