Cell shape changes underlie a large set of biological processes ranging from cell division to
cell motility. Stereotyped patterns of cell shape changes also determine tissue remodeling …

Ca2+-dependent cell–cell adhesion is regulated by the cadherin family of cell adhesion
proteins. Cadherins form trans-interactions on opposing cell surfaces which result in weak …

Cell surface receptors integrate chemical and mechanical cues to regulate a wide range of
biological processes. Integrin complexes are the mechanotransducers between the …

Spatiotemporal coordination of cell–cell adhesion involving lamellipodial interactions,
cadherin engagement, and the lateral expansion of the contact is poorly understood. Using …

Classical cadherins accumulate at cell–cell contacts as a characteristic response to
productive adhesive ligation. Such local accumulation of cadherins is a developmentally …

Mechanical stress is increasingly being shown to be a potent modulator of cell–cell
junctional morphologies in developmental and homeostatic processes. Intercellular force …

Cells integrate biochemical and mechanical information to function within multicellular
tissue. Within developing and remodeling tissues, mechanical forces contain instructive …

Epithelial cell–cell junctions are formed by apical adherens junctions (AJs), which are
composed of cadherin adhesion molecules interacting in a dynamic way with the cortical …

The motile behavior of epithelial cells located at the edge of a large wound in a monolayer of
cultured cells was analyzed. The initial cellular response is alignment of the edge with an …

Cell migration is essential for a wide range of biological processes such as embryo
morphogenesis, wound healing, regeneration, and also in pathological conditions, such as …