Tumor-induced inflammatory cytokines and the emerging diagnostic devices for cancer detection and prognosis
Chronic inflammation generated by the tumor microenvironment is known to drive cancer
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
initiation, proliferation, progression, metastasis, and therapeutic resistance. The tumor …
Emerging ELISA derived technologies for in vitro diagnostics
ELISA technology has received great attention in in vitro diagnostics (IVD) due to its high
specificity, sensitivity and high throughput. However, the traditional ELISA technology is …
specificity, sensitivity and high throughput. However, the traditional ELISA technology is …
[HTML][HTML] Biomarkers for prognosis and treatment response in COVID-19 patients
During a severe infection such as coronavirus disease 2019 (COVID-19), the level of almost
all analytes can change, presenting a correlation with disease severity and survival; …
all analytes can change, presenting a correlation with disease severity and survival; …
Machine-learning-assisted microfluidic nanoplasmonic digital immunoassay for cytokine storm profiling in COVID-19 patients
Cytokine storm, known as an exaggerated hyperactive immune response characterized by
elevated release of cytokines, has been described as a feature associated with life …
elevated release of cytokines, has been described as a feature associated with life …
Digital detection of proteins
DC Duffy - Lab on a Chip, 2023 - pubs.rsc.org
This paper reviews methods for detecting proteins based on molecular digitization, ie, the
isolation and detection of single protein molecules or singulated ensembles of protein …
isolation and detection of single protein molecules or singulated ensembles of protein …
Merging microfluidics with luminescence immunoassays for urgent point-of-care diagnostics of COVID-19
Abstract The Coronavirus disease 2019 (COVID-19) outbreak has urged the establishment
of a global-wide rapid diagnostic system. Current widely-used tests for COVID-19 include …
of a global-wide rapid diagnostic system. Current widely-used tests for COVID-19 include …
Recent progress in development and application of DNA, protein, peptide, glycan, antibody, and aptamer microarrays
GM Aparna, KKR Tetala - Biomolecules, 2023 - mdpi.com
Microarrays are one of the trailblazing technologies of the last two decades and have
displayed their importance in all the associated fields of biology. They are widely explored to …
displayed their importance in all the associated fields of biology. They are widely explored to …
Aptamer/antibody sandwich method for digital detection of SARS-CoV2 nucleocapsid protein
Nucleocapsid protein (N protein) is the most abundant protein in SARS-CoV2 and is highly
conserved, and there are no homologous proteins in the human body, making it an ideal …
conserved, and there are no homologous proteins in the human body, making it an ideal …
A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring
Organ-on-a-chip platforms have potential to offer more cost-effective, ethical, and human-
resembling models than animal models for disease study and drug discovery. Particularly …
resembling models than animal models for disease study and drug discovery. Particularly …
Machine learning-based cytokine microarray digital immunoassay analysis
Serial measurement of a large panel of protein biomarkers near the bedside could provide a
promising pathway to transform the critical care of acutely ill patients. However, attaining the …
promising pathway to transform the critical care of acutely ill patients. However, attaining the …