Rabies is a zoonotic, fatal and progressive neurological infection caused by rabies virus of
the genus Lyssavirus and family Rhabdoviridae. It affects all warm-blooded animals and the …

Viruses have evolved precise mechanisms for using the cellular physiological pathways for
their perpetuation. These virus-driven biochemical events must be separated in space and …

Protein folding in the cell requires the assistance of enzymes collectively called chaperones.
Among these, the chaperonins are 1-MDa ring-shaped oligomeric complexes that bind …

Viruses reshape the organization of the cell interior to achieve different steps of their cellular
cycle. Particularly, viral replication and assembly often take place in viral factories where …

RNA viruses are unique in their evolutionary capacity, exhibiting high mutation rates and
frequent recombination. They rapidly adapt to environmental changes, such as shifts in …

Dengue virus (DENV) infections cause the most prevalent mosquito-borne viral disease
worldwide, for which no therapies are available. DENV encodes seven non-structural (NS) …

Heat shock proteins (HSPs) are a group of cellular proteins that are induced during stress
conditions such as heat stress, cold shock, UV irradiation and even pathogenic insult. They …

The COVID-19 pandemic made imperative the search for means to end it, which requires a
knowledge of the mechanisms underpinning the multiplication and spread of its cause, the …

The cytosolic chaperonin CCT is indispensable to eukaryotic life, folding the cytoskeletal
proteins actin and tubulin along with an estimated 10% of the remaining proteome …

The eukaryotic chaperonin containing tailless complex polypeptide 1 ring complex (CCT,
also known as TCP-1 Ring Complex, TRiC/CCT) participates in the folding of 5% to 10% of …