After decades of directed research, no effective regenerative therapy is currently available to
repair the injured human heart. The epicardium, a layer of mesothelial tissue that envelops …

Palliative surgery for congenital heart disease has allowed patients with previously lethal
heart malformations to survive and, in most cases, to thrive. However, these procedures …

NRG1 (Neuregulin-1) is an effective cardiomyocyte proliferator, secreted and released by
endothelial vascular cells, and affects the cardiovascular system. It plays a major role in …

Tissue development and homeostasis are dependent upon the concerted synthesis,
maintenance, and degradation of extracellular matrix (ECM) molecules. Cardiac fibrosis is …

Although the clinical outcomes of cell therapy trials have not met initial expectations,
emerging evidence suggests that injury-mediated tissue damage might benefit from the …

Severe cardiac remodeling leading to heart failure in individuals harboring pathogenic
LMNA variants, known as cardiolaminopathy, poses a significant clinical challenge …

Background: One of the negative effects of cardiac sympathetic hyperactivity is pathologic
hypertrophy. Recent studies have indicated that large tumor suppressor (LATS) is one of the …

Death of adult cardiac myocytes and supportive tissues resulting from cardiovascular
diseases such as myocardial infarction is the proximal driver of pathological ventricular …

The Hippo signaling pathway is a highly-conserved developmental pathway that plays an
essential role in organ size control, tumor suppression, tissue regeneration and stem cell …

Abstract The Hippo Pathway is a master regulatory network that regulates proliferation, cell
growth, stemness, differentiation, and cell death. Coordination of these processes by the …