The accurate segregation of chromosomes is essential for the survival of organisms and
cells. Mistakes can lead to aneuploidy, tumorigenesis and congenital birth defects. The …

Microtubules (MTs) play roles in regulating the mechanical structure and dynamics of cells.
While MTs appear to be highly ordered structures, recent data suggest some randomness in …

During metaphase, chromosome position at the spindle equator is regulated by the forces
exerted by kinetochore microtubules and polar ejection forces. However, the role of forces …

Chromosome mis-segregation during mitosis leads to aneuploidy, which is a hallmark of
cancer and linked to cancer genome evolution. Errors can manifest as" lagging …

Kinetochores are multi-protein complexes that power chromosome movements by tracking
microtubules plus-ends in the mitotic spindle. Human kinetochores bind up to 20 …

The essential functions required for mitotic spindle assembly and chromosome biorientation
and segregation are not fully understood, despite extensive study. To illuminate the …

Chromosome alignment at the spindle equator promotes proper chromosome segregation
and depends on pulling forces exerted at kinetochore fiber tips together with polar ejection …

Current models infer that the microtubule-based mitotic spindle is built from GDP-tubulin with
small GTP caps at microtubule plus-ends, including those that attach to kinetochores …

Intracellular forces shape cellular organization and function. One example is the mitotic
spindle, a cellular machine consisting of multiple chromosomes and centrosomes which …

During mitosis, tension develops across the centromere as a result of spindle-based forces.
Metaphase tension may be critical in preventing mitotic chromosome segregation errors …