Advances and challenges in biotechnological production of chondroitin sulfate and its oligosaccharides
W Zhang, R Xu, J Chen, H Xiong, Y Wang… - International journal of …, 2023 - Elsevier
Chondroitin sulfate (CS) is a member of glycosaminoglycans (GAGs) and has critical
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …
physiological functions. CS is widely applied in medical and clinical fields. Currently, the …
[HTML][HTML] Design and biocatalytic applications of genetically fused multifunctional enzymes
Fusion proteins, understood as those created by joining two or more genes that originally
encoded independent proteins, have numerous applications in biotechnology, from …
encoded independent proteins, have numerous applications in biotechnology, from …
Characterization of interactions of dietary cholesterol with the murine and human gut microbiome
Consumption of dietary lipids, such as cholesterol, modulates the gut microbiome with
consequences for host health through the production of microbiome-derived metabolites …
consequences for host health through the production of microbiome-derived metabolites …
Engineering sulfonate group donor regeneration systems to boost biosynthesis of sulfated compounds
R Xu, W Zhang, X Xi, J Chen, Y Wang, G Du… - Nature …, 2023 - nature.com
Sulfonation as one of the most important modification reactions in nature is essential for
many biological macromolecules to function. Development of green sulfonate group donor …
many biological macromolecules to function. Development of green sulfonate group donor …
Current state on the enzymatic synthesis of glycosaminoglycans
J Gottschalk, L Elling - Current opinion in chemical biology, 2021 - Elsevier
Glycosaminoglycans (GAGs) are linear anionic polysaccharides, and most of them show a
specific sulfation pattern. GAGs have been studied for decades, and still, new biological …
specific sulfation pattern. GAGs have been studied for decades, and still, new biological …
[HTML][HTML] Heterologous production of chondroitin
Chondroitin sulfate (CS) is a glycosaminoglycan with a broad range of applications being a
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …
popular dietary supplement for osteoarthritis. Usually, CS is extracted from animal sources …
Closed-loop system driven by ADP phosphorylation from pyrophosphate affords equimolar transformation of ATP to 3′-phosphoadenosine-5′-phosphosulfate
R Xu, Y Wang, H Huang, X Jin, J Li, G Du, Z Kang - ACS Catalysis, 2021 - ACS Publications
3′-Phosphoadenosine-5′-phosphosulfate (PAPS) is a universal sulfate group donor for
all biological sulfation reactions in living organisms. Ambitions to biomanufacture sulfate …
all biological sulfation reactions in living organisms. Ambitions to biomanufacture sulfate …
Metabolic engineering of Escherichia coli for the production of an antifouling agent zosteric acid
P Zhang, J Gao, H Zhang, Y Wang, Z Liu, SY Lee… - Metabolic …, 2023 - Elsevier
Zosteric acid (ZA) is a Zostera species-derived, sulfated phenolic acid compound with
antifouling activity and has gained much attention due to its nontoxic and biodegradable …
antifouling activity and has gained much attention due to its nontoxic and biodegradable …
From steroid and drug metabolism to glycobiology, using sulfotransferase structures to understand and tailor function
Sulfotransferases are ubiquitous enzymes that transfer a sulfo group from the universal
cofactor donor 3′-phosphoadenosine 5′-phosphosulfate to a broad range of acceptor …
cofactor donor 3′-phosphoadenosine 5′-phosphosulfate to a broad range of acceptor …
Biosynthetic production of anticoagulant heparin polysaccharides through metabolic and sulfotransferases engineering strategies
JQ Deng, Y Li, YJ Wang, YL Cao, SY Xin, XY Li… - Nature …, 2024 - nature.com
Heparin is an important anticoagulant drug, and microbial heparin biosynthesis is a potential
alternative to animal-derived heparin production. However, effectively using heparin …
alternative to animal-derived heparin production. However, effectively using heparin …