Monocarboxylate transporters (SLC16): function, regulation, and role in health and disease

MA Felmlee, RS Jones, V Rodriguez-Cruz… - Pharmacological …, 2020 - ASPET
The solute carrier family 16 (SLC16) is comprised of 14 members of the monocarboxylate
transporter (MCT) family that play an essential role in the transport of important cell nutrients …

The Warburg effect revisited—lesson from the Sertoli cell

PF Oliveira, AD Martins, AC Moreira… - Medicinal research …, 2015 - Wiley Online Library
Otto Warburg observed that cancerous cells prefer fermentative instead of oxidative
metabolism of glucose, although the former is in theory less efficient. Since Warburg's …

The molecular mechanism of sex hormones on Sertoli cell development and proliferation

W Shah, R Khan, B Shah, A Khan, S Dil… - Frontiers in …, 2021 - frontiersin.org
Sustaining and maintaining the intricate process of spermatogenesis is liable upon
hormones and growth factors acting through endocrine and paracrine pathways. The Sertoli …

Dose-dependent effects of caffeine in human Sertoli cells metabolism and oxidative profile: relevance for male fertility

TR Dias, MG Alves, RL Bernardino, AD Martins… - Toxicology, 2015 - Elsevier
Caffeine is a widely consumed substance present in several beverages. There is an
increasing consumption of energetic drinks, rich in caffeine, among young individuals in …

What does androgen receptor signaling pathway in sertoli cells during normal spermatogenesis tell us?

JM Wang, ZF Li, WX Yang - Frontiers in Endocrinology, 2022 - frontiersin.org
Androgen receptor signaling pathway is necessary to complete spermatogenesis in testes.
Difference between androgen binding location in Sertoli cell classifies androgen receptor …

Effects of elevated β-estradiol levels on the functional morphology of the testis-new insights

M Leavy, M Trottmann, B Liedl, S Reese, C Stief… - Scientific reports, 2017 - nature.com
Elevated estradiol levels are correlated with male infertility. Causes of hyperestrogenism
include diseases of the adrenal cortex, testis or medications affecting the hypothalamus …

The dark side of glucose transporters in prostate cancer: Are they a new feature to characterize carcinomas?

P Gonzalez‐Menendez, D Hevia… - … journal of cancer, 2018 - Wiley Online Library
One of the hallmarks of cancer cells is the increased ability to acquire nutrients, particularly
glucose and glutamine. Proliferating cells need precursors for cell growth and NADPH …

Antidiabetic drugs: mechanisms of action and potential outcomes on cellular metabolism

MJ Meneses, BM Silva, M Sousa, R Sá… - Current …, 2015 - ingentaconnect.com
Diabetes mellitus (DM) is one of the most prevalent chronic diseases and has been a
leading cause of death in the last decades. Thus, methods to detect, prevent or delay this …

Metformin and male reproduction: effects on S ertoli cell metabolism

MG Alves, AD Martins, CV Vaz… - British journal of …, 2014 - Wiley Online Library
Background and Purpose M etformin is commonly used to treat type 2 diabetes (T2D). While
new clinical applications have been ascribed to metformin, including treatment of …

The Sertoli cell as the orchestra conductor of spermatogenesis: spermatogenic cells dance to the tune of testosterone

F Dimitriadis, C Tsiampali, N Chaliasos, P Tsounapi… - Hormones, 2015 - Springer
Spermatogenesis is contingent upon hormones and growth factors acting through endocrine
and paracrine pathways either in vivo or in vitro. Sertoli cells (SCs) furnish essential factors …