Adult somatic stem cells in various organs maintain homeostatic tissue regeneration and
enhance plasticity. Since its initial discovery five decades ago, investigations of adult …

Many central nervous system diseases currently lack effective treatment and are often
associated with defects in microvascular function, including a failure to match the energy …

Adult neurogenic niches harbor quiescent neural stem cells; however, their in vivo identity
has been elusive. Here, we prospectively isolate GFAP+ CD133+(quiescent neural stem …

Stroke is a leading cause of mortality and severe long-term disability worldwide.
Development of effective treatment or new therapeutic strategies for ischemic stroke patients …

Neural stem cells (NSCs) play vital roles in brain homeostasis and exhibit a broad repertoire
of potentially therapeutic actions following neurovascular injury. One such injury is stroke, a …

Interactions between angiogenesis and neurogenesis regulate embryonic brain
development. However, a comprehensive understanding of the stages of vascular cell …

Neural stem cells (NSCs) are self-renewing, multipotent cells which give rise to all
components of the central nervous system (CNS) during embryogenesis, but also activate in …

The Mas-related G protein–coupled receptors (Mrgprs or Mas-related genes) comprise a
subfamily of receptors named after the first discovered member, Mas. For most Mrgprs …

Adult mammalian neural stem cells are unique because of their properties, such as
differentiation capacity, self-renewal, quiescence, and also because they exist in specific …

Rapid developments in stem cell research in recent years have provided a solid foundation
for their use in medicine. Over the last few years, hundreds of clinical trials have been …