Genome-wide association studies (GWAS) were successful to identify genetic factors
robustly associated with lung cancer. This review aims to synthesize the literature in this field …

Simple Summary Tumor necrosis factor (TNF) receptor associated factor-2 (TRAF2) is an
intracellular adapter protein with E3 ligase activity, which interacts with a plethora of other …

Lung cancer is the leading cause of cancer-related deaths worldwide. To identify genetic
factors that modify the risk of lung cancer in individuals of Chinese ancestry, we performed a …

To identify genetic susceptibility loci for nasopharyngeal carcinoma (NPC), a genome-wide
association study was performed using 464,328 autosomal SNPs in 1,583 NPC affected …

Drosophila provides a powerful genetic model for studying the in vivo regulation of cell
death. In our large-scale gain-of-function screen, we identified Eiger, the first invertebrate …

Myelin-associated inhibitory factors (MAIFs) are inhibitors of CNS axonal regeneration
following injury. The Nogo receptor complex, composed of the Nogo-66 receptor 1 (NgR1) …

The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of
scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling …

The vascular and the nervous system are responsible for oxygen, nutrient, and information
transfer and thereby constitute highly important communication systems in higher …

Growth factors and other paracrine signal molecules regulate communication between cells
in all developing organs. During tooth morphogenesis, molecules in several conserved …

X-linked and autosomal forms of anhidrotic ectodermal dysplasia syndromes (HED) are
characterized by deficient development of several ectodermal organs, including hair, teeth …