Is System xc a Suitable Target for Tumour Detection and Response Assessment with Imaging?

AR Sharkey, TH Witney, GJR Cook - Cancers, 2023 - mdpi.com
Simple Summary The expression of the cysteine–glutamate cotransporter, system xc−, is
increased in cancer cells across many cancer types. Imaging system xc− provides new …

Pet oncological radiopharmaceuticals: Current status and perspectives

M Lin, RP Coll, AS Cohen, DK Georgiou, HC Manning - Molecules, 2022 - mdpi.com
Molecular imaging is the visual representation of biological processes that take place at the
cellular or molecular level in living organisms. To date, molecular imaging plays an …

The feasibility of quantitative assessment of dynamic 18F-fluorodeoxyglucose PET in Takayasu's arteritis: a pilot study

Y Duan, K Zan, M Zhao, YL Ng, H Li, M Ge… - European Journal of …, 2023 - Springer
Purpose PET has been demonstrated to be sensitive for detecting active inflammation in
Takayasu's arteritis (TAK) patients, but semi-quantitative-based assessment may be …

[HTML][HTML] Imaging at the nexus: how state of the art imaging techniques can enhance our understanding of cancer and fibrosis

A Baniasadi, JP Das, CM Prendergast… - Journal of …, 2024 - ncbi.nlm.nih.gov
Both cancer and fibrosis are diseases involving dysregulation of cell signaling pathways
resulting in an altered cellular microenvironment which ultimately leads to progression of the …

Clinical [18F]FSPG Positron Emission Tomography Imaging Reveals Heterogeneity in Tumor-Associated System xc Activity

AR Sharkey, N Koglin, ES Mittra, S Han, GJR Cook… - Cancers, 2024 - mdpi.com
Simple Summary This clinical study explored the use of the positron emission tomography
radiotracer,[18F] FSPG, for cancer imaging.[18F] FSPG measures a process involved in …

PET Imaging of Metabolism, Perfusion, and Hypoxia: FDG and Beyond

AR Pantel, SW Bae, EJ Li, SR O'Brien… - The Cancer …, 2024 - journals.lww.com
Imaging glucose metabolism with [18 F] fluorodeoxyglucose positron emission tomography
has transformed the diagnostic and treatment algorithms of numerous malignancies in …

Simplified and highly-reliable automated production of [18F]FSPG for clinical studies

M Lin, RT Ta, HC Manning - EJNMMI Radiopharmacy and Chemistry, 2023 - Springer
Abstract Background (S)-4-(3-18F-Fluoropropyl)-L-Glutamic Acid ([18F] FSPG) is a positron
emission tomography (PET) tracer that specifically targets the cystine/glutamate antiporter …

Development of Optical Nanomaterial for Enhanced Cerenkov Imaging

Q Zhang - 2022 - search.proquest.com
Cancer is a significant public health problem worldwide and is the second leading cause of
death in the United States. Imaging has increasingly been used over the last two decades to …

KOPF HALS–18F-FSPG-PET/CT bildet Aktivität von Antiporter in Gehirntumoren ab

M Wardak - thieme-connect.com
Eine Dysbalance von Glutamat kann im Gehirn zu einer Exzitotoxizität führen. Die
Regulierung der intra-und extrazellulären Transmitterkonzentration erfolgt rezeptorabhängig …

18F-FSPG-PET/CT bildet Aktivität von Antiporter in Gehirntumoren ab

S Krome - Angewandte Nuklearmedizin, 2023 - thieme-connect.com
Eine Dysbalance von Glutamat kann im Gehirn zu einer Exzitotoxizität führen. Die
Regulierung der intra-und extrazellulären Transmitterkonzentration erfolgt rezeptorabhängig …