Zinc finger proteins are transcription factors with the finger domain, which plays a significant
role in gene regulation. As the largest family of transcription factors in the human genome …

Major depressive disorder represents a serious public health challenge worldwide;
however, the underlying cellular and molecular mechanisms are mostly unknown. Here, we …

Kupffer cells (KCs) are key regulators of liver immunity composing the principal part of
hepatic macrophages even body tissue macrophages. They reside in liver sinusoids …

Liver metastases are associated with poor response to current pharmacological treatments,
including immunotherapy. We describe a lentiviral vector (LV) platform to selectively …

Background: Chitinase-3-like protein 1 (CHI3L1) is overexpressed in various types of
tumors, especially in glioma, and contributes to tumor progression. However, the definite …

Background & Aims Non-alcoholic steatohepatitis (NASH) is a chronic inflammatory disease
that can further progress to cirrhosis and hepatocellular carcinoma. However, the key …

Aspirin as a chemopreventive agent is able to restrict the tumor growth. Phosphoglycerate
mutase 1 (PGAM1) is a key enzyme of glycolysis, playing an important role in the …

Rationale: Protein palmitoylation is tightly related to tumorigenesis or tumor progression as
many oncogenes or tumor suppressors are palmitoylated. AEG-1, an oncogene, is …

Hepatocellular carcinoma (HCC) is one of the most fatal tumours worldwide and has a high
recurrence rate. Nevertheless, the mechanism of HCC genesis remains partly unexplored …

The liver is a central immunomodulator that ensures a homeostatic balance between
protection and immunotolerance. A hallmark of hepatocellular carcinoma (HCC) is the …