The nonsteroidal antiinflammatory drug diclofenac causes rare but significant cases of
serious hepatotoxicity, typically with a delayed onset (> 1–3 months). Because there is no …

Mitochondria play a critical role in generating most of the cell's energy as ATP. They are also
involved in other metabolic processes such as urea generation, haem synthesis and fatty …

Among commonly consumed anti-inflammatory and antimicrobial drugs are diclofenac
sodium (DFS) and oxytetracycline (OTC), especially in developing countries because they …

Featuring more than 4100 references, Drug-Induced Liver Disease is an invaluable
reference for gastroenterologists, hepatologists, family physicians, internists, pathologists …

Conventional materials technology has yielded clear improvements in regenerative
medicine. Ideally, however, a replacement material should mimic the living tissue …

Dipyrone (INN, metamizol) is a common analgesic used worldwide. Its widespread
prescription or over‐the‐counter use in many countries (eg, Brazil, Israel, Mexico, Russia …

Bioactivation through drug metabolism is frequently suspected as an initiating event in many
drug toxicities. The CYP450 and peroxidase enzyme systems are generally considered the …

The global embrace of the Western dietary style has necessitated the need for
supplementation with omega-3 fatty acids (N-3) to redress the imbalance in omega-6/omega …

The risk of agranulocytosis associated with the use of pyrazolone drugs at therapeutical
doses and for short periods of time has been considered to be very low. However, little or no …

Plasma and urinary levels of malondialdehyde-like products (MDA) and isoprostanes were
identified as markers of in vivo lipid peroxidation in an animal model of CCl4 poisoning. We …