Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

Abstract The Framingham Heart Study (FHS) was established in 1948 to improve
understanding of the epidemiology of coronary heart disease (CHD) in the USA. In 1961 …

Cerebral small vessel disease (SVD) is a common accompaniment of ageing. Features seen
on neuroimaging include recent small subcortical infarcts, lacunes, white matter …

Despite the global impact and advances in understanding the pathophysiology of
cerebrovascular diseases, the term “stroke” is not consistently defined in clinical practice, in …

Abstract The original Human Connectome Project yielded a rich data set on structural and
functional connectivity in a large sample of healthy young adults using improved methods of …

Two decades of epidemiological research shows that silent cerebrovascular disease is
common and is associated with future risk for stroke and dementia. It is the most common …

Both type 1 and type 2 diabetes have been associated with reduced performance on
multiple domains of cognitive function and with structural abnormalities in the brain. With an …

White matter hyperintensities are associated with increased risk of dementia and cognitive
decline. The current study investigates the relationship between white matter …

Background and Purpose—This scientific statement provides an overview of the evidence
on vascular contributions to cognitive impairment and dementia. Vascular contributions to …

Objectives To review the evidence for an association of white matter hyperintensities with
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …