Stress exposure is considered to be the main environmental cause associated with the
development of depression. Due to the limitations of currently available antidepressants, a …

Epilepsy is a chronic neurological disorder that has an extensive impact on a patient's life.
Accumulating evidence has suggested that inflammation participates in the progression of …

P2X7 receptors are members of the ATP-gated cationic channel family with a preferential
localization at the microglial cells, the resident macrophages of the brain. However, these …

Abstract Treatment of epilepsy remains a clinical challenge, with> 30% of patients not
responding to current antiseizure drugs (ASDs). Moreover, currently available ASDs are …

Epilepsy is a common and serious complication of subarachnoid hemorrhage (SAH), giving
rise to increased morbidity and mortality. It's difficult to identify patients at high risk of …

Whether synapses in appetite-regulatory brain regions undergo long-term changes in
strength in response to satiety peptides is poorly understood. Here we show that following …

Epilepsy is one of the most common neurological diseases worldwide. Anti-seizure
medications (ASMs) with anticonvulsants remain the mainstay of epilepsy treatment …

Objective: ATP-gated ionotropic P2X7 receptors (P2X7R) actively participate in epilepsy and
other neurological disorders. Neocortical nerve terminals of patients with Mesial Temporal …

Neuropathic pain (NP) is associated with sleep disturbances, which may substantially
influence the quality of life. Clinical and animal studies demonstrated that neurotransmitter is …

The rate of biological aging varies cyclically and episodically in response to changing
environmental conditions and the developmentally-controlled biological systems that sense …