The physiological control of eating: signals, neurons, and networks

AG Watts, SE Kanoski, G Sanchez-Watts… - Physiological …, 2022 - journals.physiology.org
During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Neural circuit motifs in valence processing

KM Tye - Neuron, 2018 - cell.com
How do our brains determine whether something is good or bad? How is this computational
goal implemented in biological systems? Given the critical importance of valence processing …

Cortical ensembles orchestrate social competition through hypothalamic outputs

N Padilla-Coreano, K Batra, M Patarino, Z Chen… - Nature, 2022 - nature.com
Most social species self-organize into dominance hierarchies,, which decreases aggression
and conserves energy,, but it is not clear how individuals know their social rank. We have …

A neural circuit mechanism for encoding aversive stimuli in the mesolimbic dopamine system

JW de Jong, SA Afjei, IP Dorocic, JR Peck, C Liu… - Neuron, 2019 - cell.com
Ventral tegmental area (VTA) dopamine (DA) neurons play a central role in mediating
motivated behaviors, but the circuitry through which they signal positive and negative …

Single-cell transcriptomic analysis of the lateral hypothalamic area reveals molecularly distinct populations of inhibitory and excitatory neurons

LE Mickelsen, M Bolisetty, BR Chimileski, A Fujita… - Nature …, 2019 - nature.com
The lateral hypothalamic area (LHA) coordinates an array of fundamental behaviors,
including sleeping, waking, feeding, stress and motivated behavior. The wide spectrum of …

An approximate line attractor in the hypothalamus encodes an aggressive state

A Nair, T Karigo, B Yang, S Ganguli, MJ Schnitzer… - Cell, 2023 - cell.com
The hypothalamus regulates innate social behaviors, including mating and aggression.
These behaviors can be evoked by optogenetic stimulation of specific neuronal …

Parabrachial nucleus circuit governs neuropathic pain-like behavior

L Sun, R Liu, F Guo, M Wen, X Ma, K Li, H Sun… - Nature …, 2020 - nature.com
The lateral parabrachial nucleus (LPBN) is known to relay noxious information to the
amygdala for processing affective responses. However, it is unclear whether the LPBN …

What, if, and when to move: basal ganglia circuits and self-paced action initiation

A Klaus, J Alves da Silva… - Annual review of …, 2019 - annualreviews.org
Deciding what to do and when to move is vital to our survival. Clinical and fundamental
studies have identified basal ganglia circuits as critical for this process. The main input …

Cognitive control of escape behaviour

DA Evans, AV Stempel, R Vale, T Branco - Trends in cognitive sciences, 2019 - cell.com
When faced with potential predators, animals instinctively decide whether there is a threat
they should escape from, and also when, how, and where to take evasive action. While …

Food cue regulation of AGRP hunger neurons guides learning

J Berrios, C Li, JC Madara, AS Garfield, JS Steger… - Nature, 2021 - nature.com
Abstract Agouti-related peptide (AGRP)-expressing neurons are activated by fasting—this
causes hunger,,–, an aversive state that motivates the seeking and consumption of food …