Manipulation of the inflammatory reflex as a therapeutic strategy
MJ Kelly, C Breathnach, KJ Tracey, SC Donnelly - Cell Reports Medicine, 2022 - cell.com
The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a
neural circuit through which the CNS can modulate peripheral immune responses. Signals …
neural circuit through which the CNS can modulate peripheral immune responses. Signals …
Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms
Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …
diseases, have posed a deleterious threat to human health and brought a great burden to …
Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial
Background Long-term loss of arm function after ischaemic stroke is common and might be
improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine …
improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine …
Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …
Vagus nerve stimulation enhances stable plasticity and generalization of stroke recovery
Background and Purpose—Chronic impairment of the arm and hand is a common
consequence of stroke. Animal and human studies indicate that brief bursts of vagus nerve …
consequence of stroke. Animal and human studies indicate that brief bursts of vagus nerve …
Targeted vagus nerve stimulation for rehabilitation after stroke
ND Engineer, TJ Kimberley, CN Prudente… - Frontiers in …, 2019 - frontiersin.org
Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals,
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …
Effect and safety of transcutaneous auricular vagus nerve stimulation on recovery of upper limb motor function in subacute ischemic stroke patients: a randomized pilot …
D Wu, J Ma, L Zhang, S Wang, B Tan, G Jia - Neural Plasticity, 2020 - Wiley Online Library
Background. Transcutaneous auricular vagus nerve stimulation (taVNS) is regarded as a
potential method for recovery in stroke. The effectiveness of taVNS in acute and subacute …
potential method for recovery in stroke. The effectiveness of taVNS in acute and subacute …
Vagus nerve stimulation and the cardiovascular system
MJ Capilupi, SM Kerath… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The vagus nerve plays an important role in maintaining physiological homeostasis, which
includes reflex pathways that regulate cardiac function. The link between vagus nerve …
includes reflex pathways that regulate cardiac function. The link between vagus nerve …
Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity
DR Hulsey, CM Shedd, SF Sarker, MP Kilgard… - Experimental …, 2019 - Elsevier
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific
reorganization of movement representations in the motor cortex. This effect is hypothesized …
reorganization of movement representations in the motor cortex. This effect is hypothesized …
Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury
Recovery from serious neurological injury requires substantial rewiring of neural circuits.
Precisely-timed electrical stimulation could be used to restore corrective feedback …
Precisely-timed electrical stimulation could be used to restore corrective feedback …