Manipulation of the inflammatory reflex as a therapeutic strategy

MJ Kelly, C Breathnach, KJ Tracey, SC Donnelly - Cell Reports Medicine, 2022 - cell.com
The cholinergic anti-inflammatory pathway is the efferent arm of the inflammatory reflex, a
neural circuit through which the CNS can modulate peripheral immune responses. Signals …

Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke (VNS-REHAB): a randomised, blinded, pivotal, device trial

J Dawson, CY Liu, GE Francisco, SC Cramer, SL Wolf… - The lancet, 2021 - thelancet.com
Background Long-term loss of arm function after ischaemic stroke is common and might be
improved by vagus nerve stimulation paired with rehabilitation. We aimed to determine …

Parametric characterization of neural activity in the locus coeruleus in response to vagus nerve stimulation

DR Hulsey, JR Riley, KW Loerwald… - Experimental …, 2017 - Elsevier
Vagus nerve stimulation (VNS) has emerged as a therapy to treat a wide range of
neurological disorders, including epilepsy, depression, stroke, and tinnitus. Activation of …

Vagus nerve stimulation enhances stable plasticity and generalization of stroke recovery

EC Meyers, BR Solorzano, J James, PD Ganzer… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Chronic impairment of the arm and hand is a common
consequence of stroke. Animal and human studies indicate that brief bursts of vagus nerve …

Targeted vagus nerve stimulation for rehabilitation after stroke

ND Engineer, TJ Kimberley, CN Prudente… - Frontiers in …, 2019 - frontiersin.org
Stroke is a leading cause of disability worldwide, and in approximately 60% of individuals,
upper limb deficits persist 6 months after stroke. These deficits adversely affect the functional …

Effect and safety of transcutaneous auricular vagus nerve stimulation on recovery of upper limb motor function in subacute ischemic stroke patients: a randomized pilot …

D Wu, J Ma, L Zhang, S Wang, B Tan, G Jia - Neural Plasticity, 2020 - Wiley Online Library
Background. Transcutaneous auricular vagus nerve stimulation (taVNS) is regarded as a
potential method for recovery in stroke. The effectiveness of taVNS in acute and subacute …

Vagus nerve stimulation and the cardiovascular system

MJ Capilupi, SM Kerath… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The vagus nerve plays an important role in maintaining physiological homeostasis, which
includes reflex pathways that regulate cardiac function. The link between vagus nerve …

Norepinephrine and serotonin are required for vagus nerve stimulation directed cortical plasticity

DR Hulsey, CM Shedd, SF Sarker, MP Kilgard… - Experimental …, 2019 - Elsevier
Vagus nerve stimulation (VNS) paired with forelimb training drives robust, specific
reorganization of movement representations in the motor cortex. This effect is hypothesized …

Closed-loop neuromodulation restores network connectivity and motor control after spinal cord injury

PD Ganzer, MJ Darrow, EC Meyers, BR Solorzano… - Elife, 2018 - elifesciences.org
Recovery from serious neurological injury requires substantial rewiring of neural circuits.
Precisely-timed electrical stimulation could be used to restore corrective feedback …