The exosome journey: from biogenesis to uptake and intracellular signalling
S Gurung, D Perocheau, L Touramanidou… - Cell Communication and …, 2021 - Springer
The use of exosomes in clinical settings is progressively becoming a reality, as clinical trials
testing exosomes for diagnostic and therapeutic applications are generating remarkable …
testing exosomes for diagnostic and therapeutic applications are generating remarkable …
Signaling pathways and defense mechanisms of ferroptosis
J Liu, R Kang, D Tang - The FEBS journal, 2022 - Wiley Online Library
As a type of lytic cell death driven by unrestricted lipid peroxidation and subsequent plasma
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …
membrane damage, ferroptosis occurs and develops because of sophisticated signals and …
Extracellular vesicles: a rising star for therapeutics and drug delivery
S Du, Y Guan, A Xie, Z Yan, S Gao, W Li, L Rao… - Journal of …, 2023 - Springer
Extracellular vesicles (EVs) are nano-sized, natural, cell-derived vesicles that contain the
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …
same nucleic acids, proteins, and lipids as their source cells. Thus, they can serve as natural …
Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response
Tumour cells evade immune surveillance by upregulating the surface expression of
programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) …
programmed death-ligand 1 (PD-L1), which interacts with programmed death-1 (PD-1) …
CAR exosomes derived from effector CAR-T cells have potent antitumour effects and low toxicity
Genetically engineered T cells expressing a chimeric antigen receptor (CAR) are rapidly
emerging a promising new treatment for haematological and non-haematological …
emerging a promising new treatment for haematological and non-haematological …
Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …
To degrade or not to degrade: mechanisms and significance of endocytic recycling
PJ Cullen, F Steinberg - Nature reviews Molecular cell biology, 2018 - nature.com
Newly endocytosed integral cell surface proteins are typically either directed for degradation
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …
or subjected to recycling back to the plasma membrane. The sorting of integral cell surface …
Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications
MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …
Exosomes: the next generation of endogenous nanomaterials for advanced drug delivery and therapy
W Liao, Y Du, C Zhang, F Pan, Y Yao, T Zhang, Q Peng - Acta biomaterialia, 2019 - Elsevier
Abstract Development of functional nanomaterials is of great importance and significance for
advanced drug delivery and therapy. Nevertheless, exogenous nanomaterials have a great …
advanced drug delivery and therapy. Nevertheless, exogenous nanomaterials have a great …
The role of exosomes and exosomal microRNA in cardiovascular disease
D Zheng, M Huo, B Li, W Wang, H Piao… - Frontiers in cell and …, 2021 - frontiersin.org
Exosomes are small vesicles (30–150 nm in diameter) enclosed by a lipid membrane
bilayer, secreted by most cells in the body. They carry various molecules, including proteins …
bilayer, secreted by most cells in the body. They carry various molecules, including proteins …