Metabolic engineering for the production of dicarboxylic acids and diamines

TU Chae, JH Ahn, YS Ko, JW Kim, JA Lee, EH Lee… - Metabolic …, 2020 - Elsevier
Microbial production of chemicals and materials from renewable carbon sources is
becoming increasingly important to help establish sustainable chemical industry. In this …

Bio‐based succinic acid: an overview of strain development, substrate utilization, and downstream purification

Z Dai, F Guo, S Zhang, W Zhang… - Biofuels, Bioproducts …, 2020 - Wiley Online Library
Succinic acid is an industrially important platform chemical that could be used as precursor
for the establishment of a sustainable chemical industry. Due to the depletion of crude oil …

Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase

JH Ahn, H Seo, W Park, J Seok, JA Lee, WJ Kim… - Nature …, 2020 - nature.com
Succinic acid (SA), a dicarboxylic acid of industrial importance, can be efficiently produced
by metabolically engineered Mannheimia succiniciproducens. Malate dehydrogenase …

Recent advances in microbial production of diamines, aminocarboxylic acids, and diacids as potential platform chemicals and bio-based polyamides monomers

J Son, YJ Sohn, KA Baritugo, SY Jo, HM Song… - Biotechnology …, 2023 - Elsevier
Recently, bio-based manufacturing processes of value-added platform chemicals and
polymers in biorefineries using renewable resources have extensively been developed for …

Comprehensive investigation of succinic acid production by Actinobacillus succinogenes: a promising native succinic acid producer

Q Yang, M Wu, Z Dai, F Xin, J Zhou… - Biofuels, Bioproducts …, 2020 - Wiley Online Library
The biological production of succinic acid has attracted a great deal of attention due to the
depletion of fossil fuels and concerns regarding environmental issues. As a natural producer …

Metabolic engineering of Vibrio natriegens for anaerobic succinate production

F Thoma, C Schulze, C Gutierrez‐Coto… - Microbial …, 2022 - Wiley Online Library
The biotechnological production of succinate bears serious potential to fully replace existing
petrochemical approaches in the future. In order to establish an economically viable …

Mid–Long Chain Dicarboxylic Acid Production via Systems Metabolic Engineering: Progress and Prospects

S Gu, F Zhu, L Zhang, J Wen - Journal of Agricultural and Food …, 2024 - ACS Publications
Mid-to-long-chain dicarboxylic acids (DCA i, i≥ 6) are organic compounds in which two
carboxylic acid functional groups are present at the terminal position of the carbon chain …

Unlocking the bacterial domain for industrial biotechnology applications using universal parts and tools

L De Wannemaeker, I Bervoets, M De Mey - Biotechnology advances, 2022 - Elsevier
Synthetic biology can play a major role in the development of sustainable industrial
biotechnology processes. However, the development of economically viable production …

High-level succinic acid production by overexpressing a magnesium transporter in Mannheimia succiniciproducens

JY Kim, JA Lee, JH Ahn, SY Lee - Proceedings of the National Academy of …, 2024 - pnas.org
Succinic acid (SA), a dicarboxylic acid of industrial importance, can be efficiently produced
by metabolically engineered Mannheimia succiniciproducens. Although the importance of …

Membrane engineering via trans-unsaturated fatty acids production improves succinic acid production in Mannheimia succiniciproducens

JH Ahn, JA Lee, J Bang, SY Lee - Journal of Industrial …, 2018 - academic.oup.com
Engineering of microorganisms to produce desired bio-products with high titer, yield, and
productivity is often limited by product toxicity. This is also true for succinic acid (SA), a four …