Osteoarthritis (OA) is a chronic disease and the most common orthopedic disorder. A vast
majority of the social OA burden is related to hips and knees. The prevalence of knee OA …

The inflammaging concept was introduced in 2000 by Prof. Franceschi. This was an
evolutionary or rather a revolutionary conceptualization of the immune changes in response …

Background Chronic inflammation has been associated with sarcopenia and its components
skeletal muscle strength and muscle mass. The aim of this systematic review and meta …

Oscillospira is a class of organism that often appears in high-throughput sequencing data
but has not been purely cultured and is widely present in the animal and human intestines …

Aging results in an elevated burden of senescent cells, senescence‐associated secretory
phenotype (SASP), and tissue infiltration of immune cells contributing to chronic low‐grade …

Ovarian aging refers to the process by which ovarian function declines until eventual failure.
The pathogenesis of ovarian aging is complex and diverse; oxidative stress (OS) is …

COVID-19 is highly variable in its clinical presentation, ranging from asymptomatic infection
to severe organ damage and death. We characterized the time-dependent progression of …

Both obesity and aging are associated with the development of metabolic diseases such as
type 2 diabetes and cardiovascular disease. Chronic low-grade inflammation of adipose …

The first paper on “inflammaging” published in 2001 paved the way for a unifying theory on
how and why aging turns out to be the main risk factor for the development of the most …

Osteocytes play a critical role in maintaining bone homeostasis and in regulating skeletal
response to hormones and mechanical loading. Substantial evidence have demonstrated …