Lipid nanoparticles─ from liposomes to mRNA vaccine delivery, a landscape of research diversity and advancement

R Tenchov, R Bird, AE Curtze, Q Zhou - ACS nano, 2021 - ACS Publications
Lipid nanoparticles (LNPs) have emerged across the pharmaceutical industry as promising
vehicles to deliver a variety of therapeutics. Currently in the spotlight as vital components of …

Recent progress in nanostructured smart drug delivery systems for cancer therapy: a review

MI Khan, MI Hossain, MK Hossain… - ACS Applied Bio …, 2022 - ACS Publications
Traditional treatment approaches for cancer involve intravenous chemotherapy or other
forms of drug delivery. These therapeutic measures suffer from several limitations such as …

Breast cancer: Biology, biomarkers, and treatments

K Barzaman, J Karami, Z Zarei, A Hosseinzadeh… - International …, 2020 - Elsevier
During the past recent years, various therapies emerged in the era of breast cancer. Breast
cancer is a heterogeneous disease in which genetic and environmental factors are involved …

Smart nanomaterials in cancer theranostics: challenges and opportunities

BK Kashyap, VV Singh, MK Solanki, A Kumar… - ACS …, 2023 - ACS Publications
Cancer is ranked as the second leading cause of death globally. Traditional cancer
therapies including chemotherapy are flawed, with off-target and on-target toxicities on the …

Novel nanomedicines to overcome cancer multidrug resistance

Z Su, S Dong, SC Zhao, K Liu, Y Tan, X Jiang… - Drug Resistance …, 2021 - Elsevier
Chemotherapy remains a powerful tool to eliminate malignant cells. However, the efficacy of
chemotherapy is compromised by the frequent emergence of intrinsic and acquired …

The mRNA vaccine revolution: COVID-19 has launched the future of vaccinology

Z Ye, J Harmon, W Ni, Y Li, D Wich, Q Xu - ACS nano, 2023 - ACS Publications
During the COVID-19 pandemic, mRNA (mRNA) vaccines emerged as leading vaccine
candidates in a record time. Nonreplicating mRNA (NRM) and self-amplifying mRNA (SAM) …

Specific targeting cancer cells with nanoparticles and drug delivery in cancer therapy

S Raj, S Khurana, R Choudhari, KK Kesari… - Seminars in cancer …, 2021 - Elsevier
Nanotechnology has been the latest approach for diagnosis and treatment for cancer, which
opens up a new alternative therapeutic drug delivery option to treat disease. Nanoparticles …

Nanoparticles in clinical trials: analysis of clinical trials, FDA approvals and use for COVID-19 vaccines

ED Namiot, AV Sokolov, VN Chubarev… - International journal of …, 2023 - mdpi.com
Nanoparticles are heterologous small composites that are usually between 1 and 100
nanometers in size. They are applied in many areas of medicine with one of them being …

[HTML][HTML] Lipid-laden lung mesenchymal cells foster breast cancer metastasis via metabolic reprogramming of tumor cells and natural killer cells

Z Gong, Q Li, J Shi, ET Liu, LD Shultz, G Ren - Cell metabolism, 2022 - cell.com
While the distant organ environment is known to support metastasis of primary tumors, its
metabolic roles in this process remain underdetermined. Here, in breast cancer models, we …

[HTML][HTML] Nano-based drug delivery systems: Conventional drug delivery routes, recent developments and future prospects

A Sultana, M Zare, V Thomas, TSS Kumar… - Medicine in Drug …, 2022 - Elsevier
Drug delivery can be defined as the group of approaches a drug or pharmacologically active
agent can be transported to the target cell to treat disease or health issue. Conventional …