Aryl hydrocarbon receptor (AhR) is a member of the basic helix–loop–helix–(bHLH)
superfamily of transcription factors, which are associated with cellular responses to …

Krüppel-like factor 4 (KLF4) is an evolutionarily conserved zinc finger-containing
transcription factor that regulates diverse cellular processes such as cell growth …

Skin undergoes constant self-renewal, and its functional decline is a visible consequence of
aging. Understanding human skin aging requires in-depth knowledge of the molecular and …

The two major lineages of classical dendritic cells (cDCs) express and require either IRF8 or
IRF4 transcription factors for their development and function. IRF8-dependent cDCs promote …

Glioblastoma multiforme (GBM), an aggressive tumor that typically exhibits treatment failure
with high mortality rates, is associated with the presence of cancer stem cells (CSCs) within …

The discovery of induced pluripotent stem cells (iPSCs) by Shinya Yamanaka in 2006 was
heralded as a major breakthrough of the decade in stem cell research. The ability to …

The dendritic cells (DCs) of the immune system function in innate and adaptive responses
by directing activity of various effector cells rather than serving as effectors themselves. DCs …

Direct reprogramming of somatic cells provides an opportunity to generate patient-or
disease-specific pluripotent stem cells. Such induced pluripotent stem (iPS) cells were …

Adipose tissue is an important site for lipid storage, energy homeostasis, and whole-body
insulin sensitivity. It is important to understand the mechanisms involved in adipose tissue …

Sp1-like proteins and Krüppel-like factors (KLFs) are highly related zinc-finger proteins that
are important components of the eukaryotic cellular transcriptional machinery. By regulating …