The Wnt signal transduction pathway has essential roles in the formation of the primary body
axis during development, cellular differentiation and tissue homeostasis. This animal …

Neurogenesis and tumorigenesis share signaling molecules/pathways involved in cell
proliferation, differentiation, migration, and death. Self-renewal of neural stem cells is a …

Glial cells expressing neuron‐glial antigen 2 (NG2), also known as oligodendrocyte
progenitor cells (OPCs), play a critical role in maintaining brain health. However, their ability …

WNT signaling is important in development, stem cell maintenance, and disease. WNT
ligands typically signal via receptor activation across the plasma membrane to induce β …

Human development relies on the correct replication, maintenance and segregation of our
genetic blueprints. How these processes are monitored across embryonic lineages, and why …

Cilia and Wnt signaling have a complex relationship, wherein Wnt regulates cilia and,
conversely, cilia may affect Wnt signaling. Recently, it was shown that Wnt receptors are …

Wnt signalling is an essential player in tissue formation, notably in the regulation of stem cell
function. Wnt signalling is best known for its roles in G1/S progression. However, a complex …

Robust brain development requires the tight coordination between tissue growth, neuronal
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …

Hypoxic-ischemic brain damage (HIBD) is the main cause of perinatal mortality and
neurologic complications in neonates, but it remains difficult to cure due to scarce treatments …

It is widely thought that Wnt/Lrp6 signaling proceeds through the cytoplasm and that motile
cilia are signaling-inert nanomotors. Contrasting both views, we here show in the …