Hypervalent aryliodoumiums are intensively investigated as arylating agents. They are
excellent surrogates to aryl halides, and moreover they exhibit better reactivity, which allows …

Genetically encoded small molecules (secondary metabolites) play eminent roles in
ecological interactions, as pathogenicity factors and as drug leads. Yet, these chemical …

One of the exciting movements in microbial sciences has been a refocusing and
revitalization of efforts to mine the fungal secondary metabolome. The magnitude of …

All organisms produce specialized organic molecules, ranging from small volatile chemicals
to large gene-encoded peptides, that have evolved to provide them with diverse cellular and …

Covering: 2016 to 2021 With genetic information available for hundreds of thousands of
organisms in publicly accessible databases, scientists have an unprecedented opportunity …

Addressing the ongoing antibiotic crisis requires the discovery of compounds with novel
mechanisms of action that are capable of treating drug-resistant infections. Many antibiotics …

Genome mining of biosynthetic pathways with no identifiable core enzymes can lead to
discovery of the so-called unknown (biosynthetic route)–unknown (molecular structure) …

Herbicides represent about 60% of the pesticides (by volume) used worldwide. The success
of herbicides can be attributed in part to a relatively steady discovery of one unique …

Covering: 2015 to the end of 2020 Fungal-derived polyketides, non-ribosomal peptides,
terpenoids and their hybrids contribute significantly to the chemical space of total natural …

Covering: 2010 to 2021 Organisms in nature have evolved into proficient synthetic chemists,
utilizing specialized enzymatic machinery to biosynthesize an inspiring diversity of …