Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

To defense harmful stimuli or maintain the immune homeostasis, the body produces and
recruits a superfamily of cytokines such as interleukins, interferons, chemokines etc. Among …

The role of TGF-β-induced epithelial-mesenchymal transition (EMT) in cancer cell
dissemination is well established, but the involvement of lncRNAs in TGF-β signaling is still …

Purpose: We previously demonstrated the association between epithelial-to-mesenchymal
transition (EMT) and drug response in lung cancer using an EMT signature derived in …

Background Nucleotide metabolism is a critical pathway that generates purine and
pyrimidine molecules for DNA replication, RNA synthesis, and cellular bioenergetics …

Background The process of malignant transformation, progression and metastasis of
melanoma is poorly understood. Gene expression profiling of human cancer has allowed for …

Epithelial‐to‐mesenchymal transition (EMT), a process through which epithelial tumor cells
acquire mesenchymal phenotypic properties, contributes to both metastatic dissemination …

The incidence of melanoma is increasing over the years with a still poor prognosis and the
lack of a cure able to guarantee an adequate survival of patients. Although the new immuno …

Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

Melanoma, a highly heterogeneous tumor, is comprised of a functionally diverse spectrum of
cell phenotypes and subpopulations, including stromal cells in the tumor microenvironment …