Gasdermin E (GSDME), a gene originally involved in hereditary hearing loss, has been
associated with several types of cancer in the last two decades. Recently, GSDME was …

The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA–E and Pejvakin,
PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM) …

Pyroptosis is a lytic form of cell death distinguished from apoptosis, ferroptosis, necrosis,
necroptosis, NETosis, oncosis, pyronecrosis and autophagy. Proinflammatory caspases …

Pyroptosis is a recently identified mechanism of programmed cell death related to Caspase-
1 that triggers a series of inflammatory reactions by releasing several proinflammatory …

Pyroptosis, a lytic form of programmed cell death, both stimulates effective immune
responses and causes tissue damage. Gasdermin (GSDM) proteins are a family of pore …

Gasdermins (GSDMs) belong to a protein superfamily that is found only in vertebrates and
consists of GSDMA, GSDMB, GSDMC, GSDMD, DFNA5 (aka GSDME) and DFNB59 (aka …

Background and objectives: Allergic rhinitis has complex patterns of inheritance, and single
nucleotide polymorphisms, a common genetic variation in a population, exert a significant …

Impavido (Miltefosine) is an FDA-approved drug for treating leishmaniasis and primary
amebic meningoencephalitis. We have shown previously that Miltefosine increased …

Background Gasdermin A (GSDMA) and gasdermin B (GSDMB) have been associated with
childhood and adult asthma in many populations including the Jordanian population. It is …

Objective Asthma is a heterogeneous and genetically complex respiratory disease, and
more than 300 million people are affected worldwide. In this study, frequencies of four SNPs …