Non-coding RNAs: lessons from the small nuclear and small nucleolar RNAs
Recent advances have fuelled rapid growth in our appreciation of the tremendous number,
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …
diversity and biological importance of non-coding (nc) RNAs. Because ncRNAs typically …
Caenorhabditis elegans: A transgenic model for studying age-associated neurodegenerative diseases
Neurodegenerative diseases (NDs) are a heterogeneous group of aging-associated
ailments characterized by interrupting cellular proteostasic machinery and the misfolding of …
ailments characterized by interrupting cellular proteostasic machinery and the misfolding of …
Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes
Humans have two nearly identical copies of the survival motor neuron (SMN) gene, SMN1
and SMN2. Homozygous loss of SMN1 causes spinal muscular atrophy (SMA). SMN2 is …
and SMN2. Homozygous loss of SMN1 causes spinal muscular atrophy (SMA). SMN2 is …
The SMN complex: an assembly machine for RNPs
In eukaryotic cells, the biogenesis of spliceosomal small nuclear ribonucleoproteins
(snRNPs) and likely other RNPs ismediated by an assemblyosome, the survival of motor …
(snRNPs) and likely other RNPs ismediated by an assemblyosome, the survival of motor …
Formation of the 3′ end of histone mRNA: getting closer to the end
Z Dominski, WF Marzluff - Gene, 2007 - Elsevier
Nearly all eukaryotic mRNAs end with a poly (A) tail that is added to their 3′ end by the
ubiquitous cleavage/polyadenylation machinery. The only known exceptions to this rule are …
ubiquitous cleavage/polyadenylation machinery. The only known exceptions to this rule are …
Chaperoning ribonucleoprotein biogenesis in health and disease
L Pellizzoni - EMBO reports, 2007 - embopress.org
The survival motor neuron (SMN) protein is part of a macromolecular complex that functions
in the biogenesis of small nuclear ribonucleoproteins (snRNPs)—the essential components …
in the biogenesis of small nuclear ribonucleoproteins (snRNPs)—the essential components …
Molecular functions of the SMN complex
SJ Kolb, DJ Battle, G Dreyfuss - Journal of child neurology, 2007 - journals.sagepub.com
The SMN complex is essential for the biogenesis of spliceosomal small nuclear
ribonucleoproteins and likely functions in the assembly, metabolism, and transport of a …
ribonucleoproteins and likely functions in the assembly, metabolism, and transport of a …
The Gemin5 protein of the SMN complex identifies snRNAs
The survival of motor neurons protein (SMN) is part of a large complex that contains six other
proteins, Gemins2–7. The SMN complex assembles the heptameric Sm protein core on …
proteins, Gemins2–7. The SMN complex assembles the heptameric Sm protein core on …
[HTML][HTML] Structure of a key intermediate of the SMN complex reveals Gemin2's crucial function in snRNP assembly
The SMN complex mediates the assembly of heptameric Sm protein rings on small nuclear
RNAs (snRNAs), which are essential for snRNP function. Specific Sm core assembly …
RNAs (snRNAs), which are essential for snRNP function. Specific Sm core assembly …
[HTML][HTML] Gemin5 delivers snRNA precursors to the SMN complex for snRNP biogenesis
J Yong, M Kasim, JL Bachorik, L Wan, G Dreyfuss - Molecular cell, 2010 - cell.com
The SMN complex assembles Sm cores on snRNAs, a key step in the biogenesis of
snRNPs, the spliceosome's major components. Here, using SMN complex inhibitors …
snRNPs, the spliceosome's major components. Here, using SMN complex inhibitors …