Potential of p38-MAPK inhibitors in the treatment of ischaemic heart disease
Chronic heart failure is debilitating, often fatal, expensive to treat and common. In most
patients it is a late consequence of myocardial infarction (MI). The intracellular signals …
patients it is a late consequence of myocardial infarction (MI). The intracellular signals …
Mutations that confer drug-resistance, oncogenicity and intrinsic activity on the ERK MAP kinases—current state of the art
K Smorodinsky-Atias, N Soudah, D Engelberg - Cells, 2020 - mdpi.com
Unique characteristics distinguish extracellular signal-regulated kinases (Erks) from other
eukaryotic protein kinases (ePKs). Unlike most ePKs, Erks do not autoactivate and they …
eukaryotic protein kinases (ePKs). Unlike most ePKs, Erks do not autoactivate and they …
Regulation of PKD by the MAPK p38δ in insulin secretion and glucose homeostasis
Dysfunction and loss of insulin-producing pancreatic β cells represent hallmarks of diabetes
mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38δ …
mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38δ …
p38γ is essential for cell cycle progression and liver tumorigenesis
The cell cycle is a tightly regulated process that is controlled by the conserved cyclin-
dependent kinase (CDK)–cyclin protein complex. However, control of the G0-to-G1 transition …
dependent kinase (CDK)–cyclin protein complex. However, control of the G0-to-G1 transition …
Mnk2 alternative splicing modulates the p38-MAPK pathway and impacts Ras-induced transformation
The kinase Mnk2 is a substrate of the MAPK pathway and phosphorylates the translation
initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively …
initiation factor eIF4E. In humans, MKNK2, the gene encoding for Mnk2, is alternatively …
Activator protein-1 and smad proteins synergistically regulate human follicle-stimulating hormone β-promoter activity
GnRH1 stimulates the synthesis and secretion of FSH and LH from the anterior pituitary
gland. The molecular mechanisms through which GnRH1 produces these effects in humans …
gland. The molecular mechanisms through which GnRH1 produces these effects in humans …
Genome‐wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma
L Gao, MA Smit, JJ van den Oord… - Pigment cell & …, 2013 - Wiley Online Library
The involvement of epigenetic alterations in the pathogenesis of melanoma is increasingly
recognized. Here, we performed genome‐wide DNA methylation analysis of primary …
recognized. Here, we performed genome‐wide DNA methylation analysis of primary …
Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control
Abstract p38 mitogen-activated protein kinases (MAPKs) participate in autophagic signaling;
and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including …
and previous reports suggest that pyridinyl imidazole p38 MAPK inhibitors, including …
Intrinsically active variants of all human p38 isoforms
M Avitzour, R Diskin, B Raboy, N Askari… - The FEBS …, 2007 - Wiley Online Library
The p38 mitogen‐activated protein kinases are activated in response to various extracellular
signals in eukaryotic cells and play a critical role in the cellular responses to these signals …
signals in eukaryotic cells and play a critical role in the cellular responses to these signals …
Differential Modulation of the Phosphoproteome by the MAP Kinases Isoforms p38α and p38β
D Melamed Kadosh, J Beenstock, D Engelberg… - International Journal of …, 2023 - mdpi.com
The p38 members of the mitogen-activated protein kinases (MAPKs) family mediate various
cellular responses to stress conditions, inflammatory signals, and differentiation factors …
cellular responses to stress conditions, inflammatory signals, and differentiation factors …