Wnt signaling in breast cancer: biological mechanisms, challenges and opportunities

X Xu, M Zhang, F Xu, S Jiang - Molecular cancer, 2020 - Springer
Wnt signaling is a highly conserved signaling pathway that plays a critical role in controlling
embryonic and organ development, as well as cancer progression. Genome-wide …

Wnt signaling pathway: A comprehensive review

R Hayat, M Manzoor, A Hussain - Cell biology international, 2022 - Wiley Online Library
Wnt signaling is an evolutionary cell‐to‐cell coordination mechanism and it is highly critical
for a variety of physiological processes of an organism's body, including stem cell …

The PI3K-AKT-mTOR pathway and prostate cancer: at the crossroads of AR, MAPK, and WNT signaling

BY Shorning, MS Dass, MJ Smalley… - International journal of …, 2020 - mdpi.com
Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

YS Jung, JI Park - Experimental & Molecular Medicine, 2020 - nature.com
Wnt/β-catenin signaling is implicated in many physiological processes, including
development, tissue homeostasis, and tissue regeneration. In human cancers, Wnt/β-catenin …

Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: an update

M Mehta, DS Dhanjal, KR Paudel, B Singh… - …, 2020 - Springer
Respiratory disorders, especially non-communicable, chronic inflammatory diseases, are
amongst the leading causes of mortality and morbidity worldwide. Respiratory diseases …

Wnt signaling in development and tissue homeostasis

Z Steinhart, S Angers - Development, 2018 - journals.biologists.com
The Wnt-β-catenin signaling pathway is an evolutionarily conserved cell-cell communication
system that is important for stem cell renewal, cell proliferation and cell differentiation both …

Cell biology of canonical Wnt signaling

LV Albrecht, N Tejeda-Muñoz… - Annual review of cell …, 2021 - annualreviews.org
Wnt signaling has multiple functions beyond the transcriptional effects of β-catenin
stabilization. We review recent investigations that uncover new cell physiological effects …

Wnt–β-catenin signalling in liver development, health and disease

MJ Perugorria, P Olaizola, I Labiano… - Nature reviews …, 2019 - nature.com
The canonical Wnt–β-catenin pathway is a complex, evolutionarily conserved signalling
mechanism that regulates fundamental physiological and pathological processes. Wnt–β …

Acquisition of a hybrid E/M state is essential for tumorigenicity of basal breast cancer cells

C Kröger, A Afeyan, J Mraz, EN Eaton… - Proceedings of the …, 2019 - National Acad Sciences
Carcinoma cells residing in an intermediate phenotypic state along the epithelial–
mesenchymal (E–M) spectrum are associated with malignant phenotypes, such as …

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

Y Peng, Y Xu, X Zhang, S Deng, Y Yuan, X Luo… - Molecular cancer, 2021 - Springer
Abstract Background Circular RNA (circRNA), a subclass of non-coding RNA, plays a critical
role in cancer tumorigenesis and metastasis. It has been suggested that circRNA acts as a …