Shiga toxin (Stx) is one of the most potent bacterial toxins known. Stx is found in Shigella
dysenteriae 1 and in some serogroups of Escherichia coli (called Stx1 in E. coli). In addition …

Immunosuppressive agents are commonly used in the nephrologist's practice in the
treatment of autoimmune and immune-mediated diseases and transplantation, and they are …

Atypical hemolytic uremic syndrome (aHUS), a rare variant of thrombotic microangiopathy, is
characterized by microangiopathic hemolytic anemia, thrombocytopenia, and renal …

Atypical hemolytic uremic syndrome (aHUS) and C3 glomerulopathy (C3G) are associated
with dysregulation and overactivation of the complement alternative pathway. Typically …

Endothelium is strategically located at the interface between blood and interstitial tissues,
placing thus endothelial cell as a key player in vascular homeostasis. Endothelial cells are …

Atypical hemolytic uremic syndrome (aHUS) is characterized by microangiopathic hemolytic
anemia, thrombocytopenia, and renal impairment. Complement and coagulation gene …

Introduction Atypical hemolytic uremic syndrome (aHUS) is mainly due to complement
regulatory gene abnormalities with a dominant pattern but incomplete penetrance. Thus …

The spectrum of the thrombotic microangiopathies (TMA) encompasses a heterogeneous
group of disorders with hereditary and acquired forms. Endothelial cell injury in the …

Post-hoc subgroup analysis of the negative trial of interleukin-1β receptor antagonist
(IL1RA) for septic shock suggested that patients with features of macrophage activation …

Thrombotic micro‐angiopathies (TMA) are a group of related disorders that are
characterized by thrombosis of the microvasculature and associated organ dysfunction, and …