Newer treatment strategy based on proliferative nuclear marker Ki-67 targeted therapy holds
promise for prioritized/personalized treatment options with regard to improved survival and …

Deregulation of the cell cycle underlies the aberrant cell proliferation that characterizes
cancer and loss of cell cycle checkpoint control promotes genetic instability. During the past …

CONTEXT: The natural history of renal cell carcinoma (RCC) is highly unpredictable. Small
renal masses may be accompanied by metastatic disease. Conversely, patients with locally …

Ebola virus (EBOV) causes severe human disease. During late infection, EBOV virions are
on the skin's surface; however, the permissive skin cell types and the route of virus …

Renal cell carcinomas (RCC) are emerging as a complex set of diseases that are having a
major socioeconomic impact and showing a continued rise in incidence throughout the …

A role for the minichromosome maintenance (MCM) proteins in cancer initiation and
progression is slowly emerging. Functioning as a complex to ensure a single chromosomal …

Purpose: The inflammatory enzyme indoleamine 2, 3-dioxygenase (IDO) participates in
immune tolerance and tumor immune escape processes by degradation of the essential …

Object: A large number of studies have suggested that stemness is an essential mechanism
for drug resistance, metastasis and relapse in hepatocellular carcinoma (HCC). The aim of …

Proteins necessary for the normal regulation of the cell cycle include minichromosome
maintenance protein 2 (Mcm2) and geminin. These are overexpressed in several …

Genes that are commonly deregulated in cancer are clinically attractive as candidate pan-
diagnostic markers and therapeutic targets. To globally identify such targets, we compared …