[HTML][HTML] Recent evidence in epigenomics and proteomics biomarkers for early and minimally invasive diagnosis of Alzheimer's and Parkinson's diseases

S Mayo, J Benito-León, C Peña-Bautista… - Current …, 2021 - ncbi.nlm.nih.gov
Background: Alzheimer's (AD) and Parkinson's diseases (PD) show deposits of improperly
folded modified proteins. Protein expression mechanisms are involved since the early …

Pure tone audiometry and hearing loss in Alzheimer's disease: a meta-analysis

SS Kwok, XMT Nguyen, DD Wu, RA Mudar… - Frontiers in …, 2022 - frontiersin.org
An association between age-related hearing loss (ARHL) and Alzheimer's Disease (AD) has
been widely reported. However, the nature of this relationship remains poorly understood …

Age-related central auditory processing disorder, MCI, and dementia in an older population of Southern Italy

R Sardone, P Battista, R Donghia… - … –head and Neck …, 2020 - journals.sagepub.com
Objective We explored the associations of age-related central auditory processing disorder
(CAPD) with mild cognitive impairment (MCI) and dementia in an older population-based …

Association of performance on dichotic auditory tests with risk for incident dementia and Alzheimer dementia

A Mohammed, LE Gibbons, G Gates… - … –Head & Neck …, 2022 - jamanetwork.com
Importance Age-related hearing difficulties can include problems with signal audibility and
central auditory processing. Studies have demonstrated associations between audibility and …

Sex-specific interactions between hearing and memory in older adults with Mild Cognitive Impairment: Findings from the COMPASS-ND study

F Al-Yawer, MK Pichora-Fuller, W Wittich, P Mick… - Ear and …, 2023 - journals.lww.com
Objectives: Hearing loss (HL) in older adults is associated with a decline in performance on
cognitive tasks and the risk of developing dementia. However, very few studies have …

Genome-wide methylation of mild cognitive impairment in Mexican Americans highlights genes involved in synaptic transport, alzheimer's disease-precursor …

GA Pathak, TK Silzer, J Sun, Z Zhou… - Journal of …, 2019 - content.iospress.com
The Mexican American population is among the fastest growing aging population and has a
younger onset of cognitive decline. This group is also heavily burdened with metabolic …

Multisensory, multi-tasking performance of older adults with and without subjective cognitive decline

S Carr, MK Pichora-Fuller, KZH Li, N Phillips… - Multisensory …, 2019 - brill.com
As the population ages, it is increasingly important to detect non-normative cognitive
declines as early as possible. Measures of combined sensory–motor–cognitive functioning …

Next generation cognition-aware hearing aid devices with microwave sensors: Opportunities and challenges

U Anwar, T Arslan, A Hussain, P Lomax - IEEE Access, 2022 - ieeexplore.ieee.org
The strong association between hearing loss and cognitive decline has developed into a
major health challenge that calls for early detection, diagnosis and prevention. Hearing loss …

Amyloid pathology in the central auditory pathway of 5XFAD mice appears first in auditory cortex

AP Weible, M Wehr - Journal of Alzheimer's Disease, 2022 - content.iospress.com
Background: Effective treatment of Alzheimer's disease (AD) will hinge on early detection.
This has led to the search for early biomarkers that use non-invasive testing. One possible …

5XFAD mice show early-onset gap encoding deficits in the auditory cortex

AP Weible, AJ Stebritz, M Wehr - Neurobiology of aging, 2020 - Elsevier
Early detection will be crucial for effective treatment or prevention of Alzheimer's disease.
The identification and validation of early, noninvasive biomarkers is therefore key to …