Metabolic reprogramming is an emerging hallmark of tumor cells. In order to survive in the
nutrient-deprived environment, tumor cells rewire their metabolic phenotype to provide …

De novo nucleotide biosynthetic pathway is a highly conserved and essential biochemical
pathway in almost all organisms. Both purine nucleotides and pyrimidine nucleotides are …

Generating stem-like memory T cells (TSCM) is a potential strategy to improve adoptive
immunotherapy. Elucidating optimal ways to modulate signaling pathways that enrich TSCM …

Cellular purines, particularly adenosine 5′-triphosphate (ATP), fuel many metabolic
reactions, but less is known about the direct effects of pyrimidines on cellular metabolism …

Foot-and-mouth disease virus (FMDV) is a single-stranded picornavirus that causes
economically devastating disease in even-hooved animals. There has been little research …

Glucose and glutamine play a crucial role in the metabolic reprogramming of cancer cells.
Proliferating cells metabolize glucose in the aerobic glycolysis for energy supply, and …

Dihydroorotase (DHOase) is the third enzyme in the pathway used for the biosynthesis of
pyrimidine nucleotides. In mammals, DHOase is active in a trifunctional enzyme, CAD, which …

The carnivorous pitcher plant Sarracenia purpurea exhibits many ethnobotanical uses,
including the treatments of type 2 diabetes and tuberculosis-like symptoms. In this study, we …

Pyoderma gangrenosum (PG) is a debilitating skin condition often accompanied by
inflammatory bowel disease (IBD). Strikingly,~ 40% of patients that present with PG have …

The metabolic reprogramming that occurs in cancer cells is a hallmark of cancer [1]. Indeed,
elucidating the effects of dysregulated metabolism on cancer cell phenotype constitutes the …