The key role of mitochondrial function in health and disease
I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …
[HTML][HTML] Mitochondrial dysfunction and oxidative stress in metabolic disorders—A step towards mitochondria based therapeutic strategies
Mitochondria are the powerhouses of the cell and are involved in essential functions of the
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …
cell, including ATP production, intracellular Ca 2+ regulation, reactive oxygen species …
Inflammation, metaflammation and immunometabolic disorders
GS Hotamisligil - Nature, 2017 - nature.com
Proper regulation and management of energy, substrate diversity and quantity, as well as
macromolecular synthesis and breakdown processes, are fundamental to cellular and …
macromolecular synthesis and breakdown processes, are fundamental to cellular and …
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and
ATP synthesis but also cause serious stress to various tissues, contributing to the …
ATP synthesis but also cause serious stress to various tissues, contributing to the …
[HTML][HTML] Mitochondrial dysfunction and insulin resistance: an update
MK Montgomery, N Turner - Endocrine connections, 2015 - ec.bioscientifica.com
Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …
however, a large variety of association and intervention studies as well as genetic …
Oxidative stress, insulin signaling, and diabetes
JL Rains, SK Jain - Free radical biology and medicine, 2011 - Elsevier
Oxidative stress has been implicated as a contributor to both the onset and the progression
of diabetes and its associated complications. Some of the consequences of an oxidative …
of diabetes and its associated complications. Some of the consequences of an oxidative …
Glutathione peroxidase-1 in health and disease: from molecular mechanisms to therapeutic opportunities
E Lubos, J Loscalzo, DE Handy - 2011 - liebertpub.com
Reactive oxygen species, such as superoxide and hydrogen peroxide, are generated in all
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …
cells by mitochondrial and enzymatic sources. Left unchecked, these reactive species can …
Metabolic aspects in NAFLD, NASH and hepatocellular carcinoma: the role of PGC1 coactivators
E Piccinin, G Villani, A Moschetta - Nature reviews Gastroenterology & …, 2019 - nature.com
Alterations of hepatic metabolism are critical to the development of liver disease. The
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
peroxisome proliferator-activated receptor-γ coactivators (PGC1s) are able to orchestrate, on …
A ceramide-centric view of insulin resistance
JA Chavez, SA Summers - Cell metabolism, 2012 - cell.com
The recent implementation of genomic and lipidomic approaches has produced a large
body of evidence implicating the sphingolipid ceramide in a diverse range of physiological …
body of evidence implicating the sphingolipid ceramide in a diverse range of physiological …
Impaired mitochondrial biogenesis in adipose tissue in acquired obesity
S Heinonen, J Buzkova, M Muniandy, R Kaksonen… - Diabetes, 2015 - Am Diabetes Assoc
Low mitochondrial number and activity have been suggested as underlying factors in
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …
obesity, type 2 diabetes, and metabolic syndrome. However, the stage at which …