Modulation of paraoxonase (PON1) activity
LG Costa, A Vitalone, TB Cole, CE Furlong - Biochemical pharmacology, 2005 - Elsevier
Paraoxonase 1 (PON1) is a serum enzyme closely associated with high density lipoprotein
(HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as …
(HDL). PON1 hydrolyzes several organophosphorus compounds used as insecticides, as …
The three-gene paraoxonase family: physiologic roles, actions and regulation
LP Précourt, D Amre, MC Denis, JC Lavoie, E Delvin… - Atherosclerosis, 2011 - Elsevier
The paraoxonase (PON) gene family is composed of three members (PON1, PON2, PON3)
that share considerable structural homology and are located adjacently on chromosome 7 in …
that share considerable structural homology and are located adjacently on chromosome 7 in …
Genetic and environmental factors modulating serum concentrations and activities of the antioxidant enzyme paraoxonase-1
SP Deakin, RW James - Clinical Science, 2004 - portlandpress.com
PON1 (paraoxonase-1) is an HDL (high-density lipoprotein)-associated enzyme capable of
hydrolysing diverse substrates from OP (organophosphate) toxins to oxidized phospholipids …
hydrolysing diverse substrates from OP (organophosphate) toxins to oxidized phospholipids …
Antibodies to high‐density lipoprotein and β2‐glycoprotein I are inversely correlated with paraoxonase activity in systemic lupus erythematosus and primary …
J Delgado Alves, PRJ Ames, S Donohue… - Arthritis & …, 2002 - Wiley Online Library
Objective To determine the prevalence of anti–high‐density lipoprotein (anti‐HDL)
antibodies and to establish a possible relationship between anti‐HDL, anticardiolipin …
antibodies and to establish a possible relationship between anti‐HDL, anticardiolipin …
Oxidative modification of low-density lipoprotein and immune regulation of atherosclerosis
E Matsuura, K Kobayashi, M Tabuchi… - Progress in lipid research, 2006 - Elsevier
Oxidized low-density lipoprotein (oxLDL) is thought to promote atherosclerosis through
complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and …
complex inflammatory and immunologic mechanisms that lead to lipid dysregulation and …
Simvastatin Modulates Expression of the PON1 Gene and Increases Serum Paraoxonase: A Role for Sterol Regulatory Element–Binding Protein-2
S Deakin, I Leviev, S Guernier… - … thrombosis, and vascular …, 2003 - Am Heart Assoc
Background—The HDL-associated enzyme paraoxonase protects LDLs from oxidative
stress. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) appear to …
stress. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) appear to …
Variation in paraoxonase-1 activity and atherosclerosis
Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology
Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology Log in or …
Variation in paraoxonase-1 activity and atherosclerosis : Current Opinion in Lipidology Log in or …
Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins
C Gouédard, N Koum-Besson, R Barouki… - Molecular pharmacology, 2003 - ASPET
The human paraoxonase-1 (PON-1) is a serum high-density lipoprotein-associated
phosphotriesterase secreted mainly by the liver. This enzyme is able to hydrolyze toxic …
phosphotriesterase secreted mainly by the liver. This enzyme is able to hydrolyze toxic …
The human paraoxonase gene cluster as a target in the treatment of atherosclerosis
ZG She, HZ Chen, Y Yan, H Li, DP Liu - Antioxidants & redox …, 2012 - liebertpub.com
The paraoxonase (PON) gene cluster contains three adjacent gene members, PON1, PON2,
and PON3. Originating from the same fungus lactonase precursor, all of the three PON …
and PON3. Originating from the same fungus lactonase precursor, all of the three PON …
[HTML][HTML] Implications of serum paraoxonase activity in obesity, diabetes mellitus, and dyslipidemia
Abstract Human serum paraoxonase 1 (PON1) is an enzyme with esterase activity, and is
physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL …
physically bound to high-density lipoproteins (HDL). It plays a key role in the action of HDL …