A critical analysis of codon optimization in human therapeutics
VP Mauro, SA Chappell - Trends in molecular medicine, 2014 - cell.com
Codon optimization describes gene engineering approaches that use synonymous codon
changes to increase protein production. Applications for codon optimization include …
changes to increase protein production. Applications for codon optimization include …
Human mitochondrial tRNAs: biogenesis, function, structural aspects, and diseases
Mitochondria are eukaryotic organelles that generate most of the energy in the cell by
oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a …
oxidative phosphorylation (OXPHOS). Each mitochondrion contains multiple copies of a …
The evolution of the plastid chromosome in land plants: gene content, gene order, gene function
This review bridges functional and evolutionary aspects of plastid chromosome architecture
in land plants and their putative ancestors. We provide an overview on the structure and …
in land plants and their putative ancestors. We provide an overview on the structure and …
Engineering plastid genomes: methods, tools, and applications in basic research and biotechnology
R Bock - Annual Review of Plant Biology, 2015 - annualreviews.org
The small bacterial-type genome of the plastid (chloroplast) can be engineered by genetic
transformation, generating cells and plants with transgenic plastid genomes, also referred to …
transformation, generating cells and plants with transgenic plastid genomes, also referred to …
A complete landscape of post-transcriptional modifications in mammalian mitochondrial tRNAs
In mammalian mitochondria, 22 species of tRNAs encoded in mitochondrial DNA play
crucial roles in the translation of 13 essential subunits of the respiratory chain complexes …
crucial roles in the translation of 13 essential subunits of the respiratory chain complexes …
Extreme reconfiguration of plastid genomes in the angiosperm family Geraniaceae: rearrangements, repeats, and codon usage
MM Guisinger, JV Kuehl, JL Boore… - Molecular biology and …, 2011 - academic.oup.com
Geraniaceae plastid genomes (plastomes) have experienced a remarkable number of
genomic changes. The plastomes of Erodium texanum, Geranium palmatum, and Monsonia …
genomic changes. The plastomes of Erodium texanum, Geranium palmatum, and Monsonia …
Mechanisms of functional and physical genome reduction in photosynthetic and nonphotosynthetic parasitic plants of the broomrape family
Nonphotosynthetic plants possess strongly reconfigured plastomes attributable to
convergent losses of photosynthesis and housekeeping genes, making them excellent …
convergent losses of photosynthesis and housekeeping genes, making them excellent …
Celebrating wobble decoding: Half a century and still much is new
PF Agris, ER Eruysal, A Narendran, VYP Väre… - RNA biology, 2018 - Taylor & Francis
ABSTRACT A simple post-transcriptional modification of tRNA, deamination of adenosine to
inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble …
inosine at the first, or wobble, position of the anticodon, inspired Francis Crick's Wobble …
Transfer RNAs: diversity in form and function
As the adaptor that decodes mRNA sequence into protein, the basic aspects of tRNA
structure and function are central to all studies of biology. Yet the complexities of their …
structure and function are central to all studies of biology. Yet the complexities of their …
The chemical diversity of RNA modifications
RJ Ontiveros, J Stoute, KF Liu - Biochemical Journal, 2019 - portlandpress.com
Nucleic acid modifications in DNA and RNA ubiquitously exist among all the three kingdoms
of life. This trait significantly broadens the genome diversity and works as an important …
of life. This trait significantly broadens the genome diversity and works as an important …