Adeno-associated viruses (AAVs) are commonly used for in vivo gene transfer.
Nevertheless, AAVs that provide efficient transduction across specific organs or cell …

Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold
mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report …

Intrinsically photosensitive retinal ganglion cells (ipRGCs) express the photopigment
melanopsin and regulate a wide array of light-dependent physiological processes …

Mouse genetic engineering has revolutionized our understanding of the molecular and
genetic basis of heart development and disease. This technology involves conditional tissue …

INTRODUCTION Meissner corpuscles are mechanosensory end organs that densely
occupy mammalian glabrous skin. The basic anatomy of the Meissner corpuscle and the Aβ …

OBJECTIVE Conditional gene targeting has been extensively used for in vivo analysis of
gene function in β-cell biology. The objective of this study was to examine whether mouse …

The perception of touch, including the direction of stimulus movement across the skin,
begins with activation of low-threshold mechanosensory neurons (LTMRs) that innervate the …

The basal forebrain cholinergic system modulates neuronal excitability and vascular tone
throughout the cerebral cortex and hippocampus. This system is severely affected in …

Sparse, random labelling of individual cells is a key approach to study brain circuit
organisation and development. An array of methods based on genetic engineering now …

Tamoxifen (Tm)-inducible Cre recombinases are widely used to perform gene inactivation
and lineage tracing studies in mice. Although the efficiency of inducible Cre-loxP …