Differential evolution of apoptosis, programmed necrosis, and autophagy, parthanatos is a
form of cell death mediated by poly (ADP-ribose) polymerase 1 (PARP1), which is caused by …

Diabetic cardiomyopathy (DCM) is a chronic complication of diabetes mellitus, characterized
by abnormalities of myocardial structure and function. Researches on the models of type 1 …

The aim of this article is to describe the current and potential clinical translation of
pharmacological inhibitors of poly (ADP-ribose) polymerase (PARP) for the therapy of …

The recent clinical availability of the PARP inhibitor olaparib (Lynparza) opens the door for
potential therapeutic repurposing for non‐oncological indications. Considering (a) the …

Cardiac hypertrophy and failure are characterized by transcriptional reprogramming of gene
expression. Adult cardiomyocytes in mice primarily express α-myosin heavy chain (α-MHC …

Poly (ADP-ribosyl) ation is an immediate cellular repair response to DNA damage and is
catalyzed primarily by poly (ADP-ribose) polymerase-1 (PARP1), which is the most …

Chromatin regulation provides an important means for controlling cardiac gene expression
under different physiological and pathological conditions. Processes that direct the …

Oxidative stress induces DNA breaks and PARP-1 activation which initiates mitochondrial
reactive oxygen species (ROS) production and cell death through pathways not yet …

Both heart failure with reduced ejection fraction (HFrEF) and with preserved ejection fraction
(HFpEF) are associated with high morbidity and mortality. Although many established …

The mammalian heart during its development and in response to physiological or
pathological stimuli undergoes hypertrophic enlargement, a consequence of an increase in …