Primary cilia, antenna-like sensory organelles protruding from the surface of most vertebrate
cell types, are essential for regulating signalling pathways during development and adult …

The borders between cell and developmental biology, which have always been permeable,
have largely dissolved. One manifestation is the blossoming of cilia biology, with cell and …

Motile cilia and flagella beat rhythmically on the surface of cells to power the flow of fluid and
to enable spermatozoa and unicellular eukaryotes to swim. In humans, defective ciliary …

The human genome encodes approximately 20,000 proteins, many still uncharacterised. It
has become clear that scientific research tends to focus on well-studied proteins, leading to …

Dynein-decorated doublet microtubules (DMTs) are critical components of the oscillatory
molecular machine of cilia, the axoneme, and have luminal surfaces patterned periodically …

The cilium-centrosome complex contains triplet, doublet, and singlet microtubules. The
lumenal surfaces of each microtubule within this diverse array are decorated by microtubule …

Mammalian oviducts play an essential role in female fertility by picking up ovulated oocytes
and transporting and nurturing gametes (sperm/oocytes) and early embryos. However, the …

Intraflagellar transport (IFT) is a conserved process of cargo transport in cilia that is essential
for development and homeostasis in organisms ranging from algae to vertebrates. In …

Around 12% of hereditary disease-causing mutations are in-frame nonsense mutations. The
expression of genes containing nonsense mutations potentially leads to the production of …

Cilia are microtubule-based organelles with important functions in motility and sensation.
They contribute to a broad spectrum of developmental disorders called ciliopathies and …