Abstract Nuclear DNA topoisomerase I (TOP1) is an essential human enzyme. It is the only
known target of the alkaloid camptothecin, from which the potent anticancer agents …

Green synthesis of nano-fertilizers is emerging as a potential strategy and could play a
crucial role in disease mitigation, diagnosis, or suppression. Different nanoscale devices …

First discovered as a structure-specific endonuclease that evolved to cut at the base of
single-stranded flaps, flap endonuclease (FEN1) is now recognized as a central component …

Abstract Structure-specific endonucleases (SSEs) have key roles in DNA replication,
recombination and repair, and emerging roles in transcription. These enzymes have …

Publisher Summary This chapter discusses the use of inhibitors of tyrosyl-DNA
phosphodiesterase (Tdp1) and Chk1/2 in combination with Topoisomerase I (TopI) …

Abstract Flap endonuclease-1 (FEN1) is a member of the Rad2 structure-specific nuclease
family. FEN1 possesses FEN, 5′-exonuclease and gap-endonuclease activities. The …

Most chemotherapy regimens contain at least one DNA-damaging agent that preferentially
affects the growth of cancer cells. This strategy takes advantage of the differences in cell …

Proper replication of the telomeric DNA at chromosome ends is critical for preserving
genome integrity. Yet, telomeres present challenges for the replication machinery, such as …

DNA2, a helicase/nuclease family member, plays versatile roles in processing DNA
intermediates during DNA replication and repair. Yeast Dna2 (yDna2) is essential in RNA …

Functional deficiency of the FEN1 gene has been suggested to cause genomic instability
and cancer predisposition. We have identified a group of FEN1 mutations in human cancer …