Fatty acids are primary metabolites synthesized by complex, elegant, and essential
biosynthetic machinery. Fatty acid synthases resemble an iterative assembly line, with an …

Bacterial type II fatty acid synthesis (FASII) is a target for novel antibiotic development. All
bacteria encode for mechanisms to incorporate exogenous fatty acids, and some bacteria …

The rationale for the pursuit of bacterial type 2 fatty acid synthesis (FASII) as a target for
antibacterial drug discovery in Gram-positive organisms is being debated vigorously based …

The skin represents an important barrier for pathogens and is known to produce fatty acids
that are toxic toward Gram-positive bacteria. A screen of fatty acids as growth inhibitors of …

Although biotin is an essential enzyme cofactor found in all three domains of life, our
knowledge of its biosynthesis remains fragmentary. Most of the carbon atoms of biotin are …

Bacterial type II fatty acid synthesis (FASII) is a target for the development of novel
therapeutics. Bacteria incorporate extracellular fatty acids into membrane lipids, raising the …

Peroxisomes carry out many essential lipid metabolic functions. Nearly all of these functions
require that an acyl group—either a fatty acid or the acyl side chain of a steroid derivative …

Staphylococcus and Streptococcus, two groups of major human pathogens, are equipped
with a fatty acid kinase (Fak) machinery to scavenge host fatty acids. The Fak complex is …

Acyl‐CoA and acyl‐acyl carrier protein (ACP) synthetases activate exogenous fatty acids for
incorporation into phospholipids in G ram‐negative bacteria. However, Gram‐positive …

Members of the Bacteroidetes phylum, represented by Alistipes finegoldii, are prominent
anerobic, Gram‐negative inhabitants of the gut microbiome. The lipid biosynthetic pathways …