Leveraging diet to engineer the gut microbiome

M Wolter, ET Grant, M Boudaud, A Steimle… - Nature reviews …, 2021 - nature.com
Autoimmune diseases, including inflammatory bowel disease, multiple sclerosis and
rheumatoid arthritis, have distinct clinical presentations but share underlying patterns of gut …

Developing a new class of engineered live bacterial therapeutics to treat human diseases

MR Charbonneau, VM Isabella, N Li… - Nature Communications, 2020 - nature.com
A complex interplay of metabolic and immunological mechanisms underlies many diseases
that represent a substantial unmet medical need. There is an increasing appreciation of the …

Emerging prospects of macro-and microalgae as prebiotic

AK Patel, RR Singhania, MK Awasthi, S Varjani… - Microbial Cell …, 2021 - Springer
Macro-and microalgae-based foods are becoming popular due to their high nutritious value.
The algal biomass is enriched with polysaccharides, protein, polyunsaturated fatty acids …

Environmental fluctuations and their effects on microbial communities, populations and individuals

J Nguyen, J Lara-Gutiérrez… - FEMS microbiology …, 2021 - academic.oup.com
From the homeostasis of human health to the cycling of Earth's elements, microbial activities
underlie environmental, medical and industrial processes. These activities occur in chemical …

Systematic mining of the human microbiome identifies antimicrobial peptides with diverse activity spectra

AM King, Z Zhang, E Glassey, P Siuti, J Clardy… - Nature …, 2023 - nature.com
Human-associated bacteria secrete modified peptides to control host physiology and
remodel the microbiota species composition. Here we scanned 2,229 Human Microbiome …

Therapeutic opportunities in inflammatory bowel disease: mechanistic dissection of host-microbiome relationships

DR Plichta, DB Graham, S Subramanian, RJ Xavier - Cell, 2019 - cell.com
The current understanding of inflammatory bowel disease (IBD) pathogenesis implicates a
complex interaction between host genetics, host immunity, microbiome, and environmental …

One health relationships between human, animal, and environmental microbiomes: a mini-review

P Trinh, JR Zaneveld, S Safranek… - Frontiers in public …, 2018 - frontiersin.org
The One Health concept stresses the ecological relationships between human, animal, and
environmental health. Much of the One Health literature to date has examined the transfer of …

[HTML][HTML] Phage-delivered CRISPR-Cas9 for strain-specific depletion and genomic deletions in the gut microbiome

KN Lam, P Spanogiannopoulos, P Soto-Perez… - Cell Reports, 2021 - cell.com
Mechanistic insights into the role of the human microbiome in the predisposition to and
treatment of disease are limited by the lack of methods to precisely add or remove microbial …

[HTML][HTML] Rational use of prebiotics for gut microbiota alterations: Specific bacterial phylotypes and related mechanisms

S Wang, Y Xiao, F Tian, J Zhao, H Zhang, Q Zhai… - Journal of Functional …, 2020 - Elsevier
Prebiotics play a widely recognized role in the regulation of intestinal microbiota, but most
related studies have not been explored beyond the genus level. In recent years, some newly …

Talk to your gut: the oral-gut microbiome axis and its immunomodulatory role in the etiology of rheumatoid arthritis

M du Teil Espina, G Gabarrini… - FEMS microbiology …, 2019 - academic.oup.com
Microbial communities inhabiting the human body, collectively called the microbiome, are
critical modulators of immunity. This notion is underpinned by associations between …