A diverse array of sex determination (SD) mechanisms, encompassing environmental to
genetic, have been found to exist among vertebrates, covering a spectrum from fixed SD …

The discovery of the Sry gene in 1990 triggered a revolution in our understanding of sex
determination. More recently, advances in non-model organisms have been fuelled by the …

Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Background Disorders of sex development (DSD) are congenital conditions in which
chromosomal, gonadal, or phenotypic sex is atypical. Clinical management of DSD is often …

Given the anthropometric differences between men and women and previous evidence of
sex-difference in genetic effects, we conducted a genome-wide search for sexually …

Context: Disorders of sex development (DSD) are clinical conditions where there is a
discrepancy between the chromosomal sex and the phenotypic (gonadal or genital) sex of …

Formerly known as' intersex'conditions, disorders of sex development (DSDs) are congenital
conditions in which chromosomal, gonadal or anatomical sex is atypical. A complete …

Mammalian sex determination is the unique process whereby a single organ, the bipotential
gonad, undergoes a developmental switch that promotes its differentiation into either a testis …

Disorders of sex development (DSD) are congenital conditions in which the development of
chromosomal, gonadal, or anatomical sex is atypical. Many of the genes required for gonad …

Mammalian sex determination hinges on the development of ovaries or testes, with testis
fate being triggered by the expression of the transcription factor sex-determining region Y …