The role of ROS in tumour development and progression
EC Cheung, KH Vousden - Nature Reviews Cancer, 2022 - nature.com
Eukaryotic cells have developed complex systems to regulate the production and response
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour …
The pentose phosphate pathway in health and disease
The pentose phosphate pathway (PPP) is a glucose-oxidizing pathway that runs in parallel
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
to upper glycolysis to produce ribose 5-phosphate and nicotinamide adenine dinucleotide …
Oxidative stress in cancer cell metabolism
Reactive oxygen species (ROS) are important in regulating normal cellular processes
whereas deregulated ROS leads to the development of a diseased state in humans …
whereas deregulated ROS leads to the development of a diseased state in humans …
NAD+ metabolism: pathophysiologic mechanisms and therapeutic potential
Nicotinamide adenine dinucleotide (NAD+) and its metabolites function as critical regulators
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
to maintain physiologic processes, enabling the plastic cells to adapt to environmental …
Tumor glycolysis, an essential sweet tooth of tumor cells
Cancer cells undergo metabolic alterations to meet the immense demand for energy,
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
building blocks, and redox potential. Tumors show glucose-avid and lactate-secreting …
A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics
Ferroptosis, an emerging type of cell death found in the past decades, features specifically
lipid peroxidation during the cell death process commonly by iron accumulation …
lipid peroxidation during the cell death process commonly by iron accumulation …
Dietary fructose improves intestinal cell survival and nutrient absorption
Fructose consumption is linked to the rising incidence of obesity and cancer, which are two
of the leading causes of morbidity and mortality globally,. Dietary fructose metabolism …
of the leading causes of morbidity and mortality globally,. Dietary fructose metabolism …
Aspects of the tumor microenvironment involved in immune resistance and drug resistance
K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …
NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications
HQ Ju, JF Lin, T Tian, D Xie, RH Xu - Signal transduction and targeted …, 2020 - nature.com
Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all
organisms, and provides the reducing power for anabolic reactions and redox balance …
organisms, and provides the reducing power for anabolic reactions and redox balance …
The effects of heavy metals on human metabolism
Z Fu, S Xi - Toxicology mechanisms and methods, 2020 - Taylor & Francis
As technology continues to advance, heavy metals in drinking water have exceeded
recommended limits from regulators around the world. The main source of human exposure …
recommended limits from regulators around the world. The main source of human exposure …