Chemokine receptors are members of the G protein-coupled receptor superfamily. These
receptors are intimately involved in cell movement, and thus play a critical role in several …

The ability of dendritic cells (DCs) to initiate and orchestrate immune responses is a
consequence of their localization within tissues and their specialized capacity for …

Chemokines are pivotal regulators of cell migration during continuous immune surveillance,
inflammation, homeostasis, and development. Chemokine binding to their 7-transmembrane …

A prominent activity of the chemokine system is the regulation of leukocyte trafficking. Here
we summarize recent findings on the initial steps in chemokine receptor–induced signal …

G protein-coupled receptors (GPCRs) play important roles in inflammation. Inflammatory
cells such as polymorphonuclear leukocytes (PMN), monocytes and macrophages express …

Mechanisms that control mobilization of cytosolic calcium [Ca 2+] i are key for regulation of
numerous eukaryotic cell functions. One such paradigmatic mechanism involves activation …

Simple Summary Breast cancer remains the most common malignancy in women. In this
review, we explore the role of the CXCL12/CXCR4 pathway in breast cancer. We show that …

Intravenously-applied bacteria tend to accumulate in tumors and can sporadically lead to
tumor regression. Systemic administration of attenuated Salmonella typhimurium is safe and …

Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to joint damage and
even disability. Although there are various clinical therapies for RA, some patients still have …

The chemokines are a family of chemotactic cytokines that mediate their activity by acting on
seven-transmembrane-spanning G protein-coupled receptors. Both the ability of the …