The human genome is organized into multiple structural layers, ranging from chromosome
territories to progressively smaller substructures, such as topologically associating domains …

The impact of variations in the three-dimensional structure of the genome has been
recognized, but solid cancer tissue studies are limited. Here, we performed integrated deep …

Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate
cancer (PCa) growth and differentiation. This process involves a complex interplay of …

Transposable elements hold regulatory functions that impact cell fate determination by
controlling gene expression. However, little is known about the transcriptional machinery …

Genome-wide association studies (GWASs) have identified more than 200 prostate cancer
(PrCa) risk regions, which provide potential insights into causal mechanisms. Multiple lines …

Many genetic variants affect disease risk by altering context-dependent gene regulation.
Such variants are difficult to study mechanistically using current methods that link genetic …

Prostate cancer aggressiveness and metastatic potential are influenced by gene expression
and genomic aberrations, features that can be influenced by the 3D structure of …

Structural variants (SVs) represent a major source of aberration in tumour genomes. Given
the diversity in the size and type of SVs present in tumours, the accurate detection and …

Simple Summary Epigenetics, which leads to specific differentiation events and determines
gene expression states, has been recognized as a developmental landscape. Epigenetic …

Highlights•3D genome organization undergoes dramatic changes in cancer.•Oncogenes
can be ectopically activated by SV-induced enhancer hijacking.•Tumor suppressor genes …