The roles of serotonin in neuropsychiatric disorders

M Pourhamzeh, FG Moravej, M Arabi… - Cellular and molecular …, 2022 - Springer
The serotonergic system extends throughout the central nervous system (CNS) and the
gastrointestinal (GI) tract. In the CNS, serotonin (5-HT, 5-hydroxytryptamine) modulates a …

The central extended amygdala in fear and anxiety: Closing the gap between mechanistic and neuroimaging research

AS Fox, AJ Shackman - Neuroscience letters, 2019 - Elsevier
Anxiety disorders impose a staggering burden on public health, underscoring the need to
develop a deeper understanding of the distributed neural circuits underlying extreme fear …

Single-cell activity and network properties of dorsal raphe nucleus serotonin neurons during emotionally salient behaviors

GE Paquelet, K Carrion, CO Lacefield, P Zhou, R Hen… - Neuron, 2022 - cell.com
The serotonin system modulates a wide variety of emotional behaviors and states, including
reward processing, anxiety, and social interaction. To reveal the underlying patterns of …

[HTML][HTML] Directed evolution of a selective and sensitive serotonin sensor via machine learning

EK Unger, JP Keller, M Altermatt, R Liang, A Matsui… - Cell, 2020 - cell.com
Serotonin plays a central role in cognition and is the target of most pharmaceuticals for
psychiatric disorders. Existing drugs have limited efficacy; creation of improved versions will …

Serotonin receptors in depression and anxiety: Insights from animal studies

E Żmudzka, K Sałaciak, J Sapa, K Pytka - Life sciences, 2018 - Elsevier
Serotonin regulates many physiological processes including sleep, appetite, and mood.
Thus, serotonergic system is an important target in the treatment of psychiatric disorders …

Reciprocal control of obesity and anxiety–depressive disorder via a GABA and serotonin neural circuit

G Xia, Y Han, F Meng, Y He, D Srisai, M Farias… - Molecular …, 2021 - nature.com
The high comorbidity between obesity and mental disorders, such as depression and
anxiety, often exacerbates metabolic and neurological symptoms significantly. However …

The receptor hypothesis and the pathogenesis of depression: Genetic bases and biological correlates

HQ Wang, ZZ Wang, NH Chen - Pharmacological research, 2021 - Elsevier
Depression has become one of the most prevalent neuropsychiatric disorders characterized
by anhedonia, anxiety, pessimism, or even suicidal thoughts. Receptor theory has been …

Recent advancement in nanosensors for neurotransmitters detection: Present and future perspective

N Chauhan, S Soni, P Agrawal, YPS Balhara… - Process Biochemistry, 2020 - Elsevier
Neurotransmitters maintain physiological condition and behaviour of the brain and body.
Studies on transmitting mechanisms and change in concentration of particular …

[HTML][HTML] Dorsal raphe serotonergic neurons suppress feeding through redundant forebrain circuits

I Aklan, N Sayar-Atasoy, F Deng, H Kim, Y Yavuz… - Molecular …, 2023 - Elsevier
Objective Serotonin (5HT) is a well-known anorexigenic molecule, and 5HT neurons of
dorsal raphe nucleus (DRN) have been implicated in suppression of feeding; however, the …

Rosemary (Rosmarinus officinalis L.) hydrosol based on serotonergic synapse for insomnia

T Li, W Wang, Q Guo, J Li, T Tang, Y Wang… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Rosemary (Rosmarinus officinalis L.) has been
widely used as a traditional remedy for insomnia, depression and anxiety in China and …