Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants

AT Jan, M Azam, K Siddiqui, A Ali, I Choi… - International journal of …, 2015 - mdpi.com
Heavy metals, which have widespread environmental distribution and originate from natural
and anthropogenic sources, are common environmental pollutants. In recent decades, their …

Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain

V Karri, M Schuhmacher, V Kumar - Environmental toxicology and …, 2016 - Elsevier
Human exposure to toxic heavy metals is a global challenge. Concurrent exposure of heavy
metals, such as lead (Pb), cadmium (Cd), arsenic (As) and methylmercury (MeHg) are …

Association between heavy metal exposure and Parkinson's disease: a review of the mechanisms related to oxidative stress

S Pyatha, H Kim, D Lee, K Kim - Antioxidants, 2022 - mdpi.com
Parkinson's disease (PD) is a gradually progressing neurodegenerative condition that is
marked by a loss of motor coordination along with non-motor features. Although the precise …

Metals, oxidative stress and neurodegeneration: a focus on iron, manganese and mercury

M Farina, DS Avila, JBT Da Rocha… - Neurochemistry …, 2013 - Elsevier
Essential metals are crucial for the maintenance of cell homeostasis. Among the 23
elements that have known physiological functions in humans, 12 are metals, including iron …

Mercury toxicity and neurodegenerative effects

A Carocci, N Rovito, MS Sinicropi, G Genchi - Reviews of environmental …, 2014 - Springer
Neurodegeneration is a broadly defined term that describes the loss of neuronal structure
and function, and produces disorders known as neurodegenerative diseases. A common …

Mechanisms of methylmercury-induced neurotoxicity: evidence from experimental studies

M Farina, JBT Rocha, M Aschner - Life sciences, 2011 - Elsevier
Neurological disorders are common, costly, and can cause enduring disability. Although
mostly unknown, a few environmental toxicants are recognized causes of neurological …

Biomarkers of mercury toxicity: Past, present, and future trends

V Branco, S Caito, M Farina… - Journal of Toxicology …, 2017 - Taylor & Francis
Mercury (Hg) toxicity continues to represent a global health concern. Given that human
populations are mostly exposed to low chronic levels of mercurial compounds …

Quercetin and the mitochondria: a mechanistic view

MR de Oliveira, SM Nabavi, N Braidy, WN Setzer… - Biotechnology …, 2016 - Elsevier
Quercetin is an important flavonoid that is ubiquitously present in the diet in a variety of fruits
and vegetables. It has been traditionally viewed as a potent antioxidant and anti …

Oxidative stress in MeHg-induced neurotoxicity

M Farina, M Aschner, JBT Rocha - Toxicology and applied pharmacology, 2011 - Elsevier
Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological
and developmental deficits in animals and humans. Although the molecular mechanisms …

Glutathione antioxidant system and methylmercury-induced neurotoxicity: An intriguing interplay

M Farina, M Aschner - Biochimica et Biophysica Acta (BBA)-General …, 2019 - Elsevier
Methylmercury (MeHg) is a toxic chemical compound naturally produced mainly in the
aquatic environment through the methylation of inorganic mercury catalyzed by aquatic …