Extracellular nucleotides (eg, ATP, ADP, UTP, UDP) released by inflammatory cells interact
with specific purinergic P2 type receptors to modulate their recruitment and activation. The …

ATP, NAD+, and nucleic acids are abundant purines that, in addition to having critical
intracellular functions, have evolved extracellular roles as danger signals released in …

Extracellular adenosine triphosphate (ATP) serves as a signal for diverse physiological
functions, including spread of calcium waves between astrocytes, control of vascular oxygen …

Adenosine triphosphate (ATP) plays a fundamental role in cellular communication, with its
extracellular accumulation triggering purinergic signaling cascades in a diversity of cell …

Efficient neuronal signaling in the central nervous system strictly depends on a well‐
balanced microenvironment around glial cells, synapses, and axons. Unique features of the …

Both purinergic signaling through nucleotides such as ATP (adenosine 5′-triphosphate)
and noradrenergic signaling through molecules such as norepinephrine regulate vascular …

The pannexins (Panxs) are a family of chordate proteins homologous to the invertebrate gap
junction forming proteins named innexins. Three distinct Panx paralogs (Panx1, Panx2, and …

Migraines constitute a common neurological and headache disorder affecting around 15%
of the world's population. In addition to other mechanisms, neurogenic neuroinflammation …

Neurological disorders represent major health concerns in terms of comorbidity and
mortality worldwide. Despite a tremendous increase in our understanding of the …

Hypertension is one of the most common risk factors for developing chronic cardiovascular
diseases, including hypertensive nephropathy. Within the glomerulus, hypertension causes …