Alzheimer's disease (AD) is the most common neurodegenerative disorder seen in age-
dependent dementia. There is currently no effective treatment for AD, which may be …

Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

The endosomal-lysosomal system is made up of a set of intracellular membranous
compartments that dynamically interconvert, which is comprised of early endosomes …

Alzheimer's disease (AD) is the most prevalent form of dementia which affects people older
than 60 years of age. In AD, the dysregulation of the amyloid-beta (Aβ) level leads to the …

The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

Insulin performs unique functions within the CNS. Produced nearly exclusively by the
pancreas, insulin crosses the blood–brain barrier (BBB) using a saturable transporter …

Pericyte loss and deficient vascular platelet-derived growth factor receptor-β (PDGFRβ)
signaling are prominent features of the blood–brain barrier breakdown described in …

According to the neurovascular hypothesis, impairment of low-density lipoprotein receptor–
related protein-1 (LRP1) in brain capillaries of the blood-brain barrier (BBB) contributes to …

Among the LDL receptor (LDLR) family members, the roles of LDLR-related protein (LRP) 1
in the pathogenesis of Alzheimer's disease (AD), especially late-onset AD, have been the …

The vast majority of Alzheimer's disease (AD) cases are late-onset and their development is
probably influenced by both genetic and environmental risk factors. A strong genetic risk …